INSTANTANEOUS PRESSURE-VOLUME RELATIONSHIP OF THE CANINE RIGHT VENTRICLE
INSTANTANEOUS PRESSURE-VOLUME RELATIONSHIP OF THE CANINE RIGHT VENTRICLE
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DOI：
10.1161/01.res.44.3.309
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发表时间：
1979-01-01
影响因子：
20.1
通讯作者：
WEISFELDT, ML
中科院分区：
文献类型：
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作者：
MAUGHAN, WL;SHOUKAS, AA;WEISFELDT, ML
在11只犬心脏上研究了右室瞬时等容和射血压力-容量关系，以表征右室收缩状态。通过连接到一个特殊的容量负荷和转换室的右室内充满水的薄乳胶气囊来测量容量。用安装在气球内的微型压力传感器测量压力。通过改变容积室上方的空气体积来改变加载条件。压力和容量数据是从同一收缩模式下恒定收缩状态下的多个心搏采集的，同时左心室被排出到空气中。对从收缩开始起以20ms为间隔的每个等时压力-体积数据集进行线性回归分析，显示压力和体积之间存在线性相关性。在整个心动周期中，回归线的斜率和体积截距随时间变化。回归线的最大斜率(Emax)平均为2.50±-。0.49毫米汞柱/毫升(平均值+-SD)用于弹射节拍和2.68.+-。等容搏动时为0.55毫米汞/毫升。肾上腺素12.5ug/min和25.0ug/min分别使Emax增加31%和62%(P<；0.005)。在生理范围内，等容收缩模式和射血模式下的右室瞬时压力-容量关系显然是线性的，这两种收缩模式并不具有相同的关系。这些压力-体积关系曲线的斜率随着收缩状态的变化而变化。
The instantaneous isovolumic and ejecting pressure-volume relationship of the right ventricle was studied in 11 cross-circulated, isolated canine hearts to characterize the right ventricular contractile state. Volume was measured by a water-filled, thin latex balloon in the right ventricle connected to a special volume loading and transducing chamber. Pressure was measured with a miniature pressure transducer mounted within the balloon. Variations in loading conditions were made by changing the volume of air above the volumetric chamber. The pressure and volume data were collected from multiple beats under a constant contractile state in the same mode of contraction while the left ventricle was vented to air. Linear regression analysis applied to each of the isochronal pressure-volume data sets at 20 ms intervals from the onset of contraction showed a linear correlation between pressure and volume. The slope and the volume intercept of the regression lines changed with time throughout the cardiac cycle. The maximal slope of the regression line (Emax) averaged 2.50 .+-. 0.49 mm Hg/ml (mean .+-. SD) for ejecting beats and 2.68 .+-. 0.55 mm Hg/ml for isovolumic beats. Epinephrine infusions of 12.5 .mu.g/min and 25.0 .mu.g/min increased Emax by 31 and 62%, respectively (P < 0.005). Apparently the instantaneous pressure-volume relationships of the right ventricle in the isovolumic and ejecting modes are linear within the physiological range; the 2 modes of contraction do not have an identical relationship. The slope of these pressure-volume relationship curves changes with a change in the contractile state.