EFFECT OF AGE ON D(2)-DOPAMINE RECEPTORS IN NORMAL HUMAN BRAIN MEASURED BY POSITRON EMISSION TOMOGRAPHY AND C-11 RACLOPRIDE
EFFECT OF AGE ON D(2)-DOPAMINE RECEPTORS IN NORMAL HUMAN BRAIN MEASURED BY POSITRON EMISSION TOMOGRAPHY AND C-11 RACLOPRIDE
复制标题
DOI：
10.1001/archneur.1993.00540050026010
复制
发表时间：
1993-05-01
影响因子：
--
通讯作者：
LOCHER, J
中科院分区：
文献类型：
--
作者：
ANTONINI, A;LEENDERS, KL;LOCHER, J
人类尸检和动物实验结果表明，随着年龄的增长，大脑多巴胺能神经元系统的下降。在这项研究中，放射性示踪剂碳11标记的雷氯必利和正电子发射断层扫描，以确定年龄对纹状体D2多巴胺受体的影响，在32名健康志愿者（年龄范围，21至68岁，中位数，31岁）。计算每例受试者壳核、尾状核和其他脑区的特异性C-11-雷氯必利结合指数。壳核和尾状核的特异性示踪剂摄取指数随年龄增长而显著降低。这种下降在30年前是急剧的，但之后有所减缓。大约30岁后，发现壳核中特异性C-11-雷氯必利结合的下降率为每年0.6%。我们的研究结果表明，D2多巴胺受体结合位点（主要位于突触后）减少作为正常老化的结果与突触前黑质纹状体多巴胺能神经元系统的下降平行。
Human postmortem and animal experimental results suggest a decline of the cerebral dopaminergic neuronal system with age. In this study, the radiotracer carbon 11-labeled-raclopride and positron emission tomography were applied to determine the effect of age on striatal D2 dopamine receptors in 32 healthy volunteer subjects (age range, 21 to 68 years; median, 31 years). An index of specific C-11-raclopride binding was calculated for putamen, caudate nucleus, and other brain regions in each subject. A significant decrease with age of the index for specific tracer uptake was found in putamen and caudate nucleus. The decrease was steep until 30 years, but slower afterward. After approximately 30 years of age, the decline of specific C-11-raclopride binding in putamen was found to be 0.6% per year. Our results suggest that D2 dopamine receptor binding sites (mainly postsynaptically located) decrease as a consequence of normal aging in parallel with the decline of the presynaptic nigrostriatal dopaminergic neuronal system.