Structural and functional features of central nervous system lymphatic vessels.
Structural and functional features of central nervous system lymphatic vessels.
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DOI：
10.1038/nature14432
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发表时间：
2015-07-16
期刊：
影响因子：
64.8
通讯作者：
Kipnis J
中科院分区：
文献类型：
--
作者：
Louveau A;Smirnov I;Keyes TJ;Eccles JD;Rouhani SJ;Peske JD;Derecki NC;Castle D;Mandell JW;Lee KS;Harris TH;Kipnis J
中枢神经系统的特征之一是缺乏经典的淋巴引流系统。尽管现在公认CNS经历在脑膜隔室内发生的恒定免疫监视，但对支配免疫细胞从CNS进入和离开的机制仍然知之甚少。在寻找T细胞进出脑膜的通道时，我们发现了硬脑膜窦内的功能性淋巴管。这些结构表达淋巴管内皮细胞的所有分子标志，能够携带来自CSF的液体和免疫细胞，并连接到颈深淋巴结。迄今为止，这些血管的独特位置可能阻碍了它们的发现，从而促成了CNS中不存在淋巴管系统的长期概念。CNS淋巴系统的发现可能需要重新评估神经免疫学的基本假设，并为与免疫系统功能障碍相关的神经炎症和神经退行性疾病的病因学提供新的线索。
One of the characteristics of the CNS is the lack of a classical lymphatic drainage system. Although it is now accepted that the CNS undergoes constant immune surveillance that takes place within the meningeal compartment, the mechanisms governing the entrance and exit of immune cells from the CNS remain poorly understood. In searching for T cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the CSF, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the CNS. The discovery of the CNS lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and shed new light on the etiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.