Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration.
Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration.
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DOI：
10.2147/ijn.s47378
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发表时间：
2013
影响因子：
8
通讯作者：
Pande G
中科院分区：
文献类型：
--
作者：
Mushahary D;Sravanthi R;Li Y;Kumar MJ;Harishankar N;Hodgson PD;Wen C;Pande G
新的可生物降解植入物和设备的发展是必要的，以满足再生骨科手术日益增长的需求。在制定新的植入材料时，一个重要的考虑因素是它们应该在物理化学和生物上模拟骨样特性。在早期的研究中，我们已经开发并表征了镁基可生物降解合金，特别是镁锆（Mg-Zr）合金。本文报道了含不同量锶或钙的四种Mg-Zr合金的生物学特性。将合金植入新西兰大白兔股骨小腔内，对新诱导的骨组织进行定量和定性评价。实验动物30只，每种种植体3只，采用组织学、免疫组织化学和放射学方法对骨诱导进行评估；未植入物的股骨空腔作为对照组，观察相同时间。我们的结果表明，含有适量锶的Mg-Zr合金比其他合金更有效地诱导高质量的矿化骨。我们的结果已经在合金的物理化学和生物学特性的背景下进行了讨论，它们可以在确定未来几代生物可降解骨科植入物的性质方面非常有用。
Development of new biodegradable implants and devices is necessary to meet the increasing needs of regenerative orthopedic procedures. An important consideration while formulating new implant materials is that they should physicochemically and biologically mimic bone-like properties. In earlier studies, we have developed and characterized magnesium based biodegradable alloys, in particular magnesium-zirconium (Mg-Zr) alloys. Here we have reported the biological properties of four Mg-Zr alloys containing different quantities of strontium or calcium. The alloys were implanted in small cavities made in femur bones of New Zealand White rabbits, and the quantitative and qualitative assessments of newly induced bone tissue were carried out. A total of 30 experimental animals, three for each implant type, were studied, and bone induction was assessed by histological, immunohistochemical and radiological methods; cavities in the femurs with no implants and observed for the same period of time were kept as controls. Our results showed that Mg-Zr alloys containing appropriate quantities of strontium were more efficient in inducing good quality mineralized bone than other alloys. Our results have been discussed in the context of physicochemical and biological properties of the alloys, and they could be very useful in determining the nature of future generations of biodegradable orthopedic implants.