High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
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DOI：
10.1086/343813
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发表时间：
2002-10-15
影响因子：
6.4
通讯作者：
Rothman, AL
中科院分区：
文献类型：
--
作者：
Libraty, DH;Young, PR;Rothman, AL
感染四种登革热病毒中的任何一种都会产生一系列临床疾病，从轻度未分化发热性疾病到登革热（DF）再到可能危及生命的登革出血热（DHF）。登革出血热的发病率和死亡率可以通过早期住院和精心的支持性护理来降低。为了确定其作为DHF预测因子的有效性，在一项前瞻性医院研究中，对32名登革热-2病毒感染儿童的血浆分泌的登革热病毒非结构蛋白NS1 （sNS1）水平进行了每日测定。血浆中游离sNS1水平与病毒血症水平相关，DHF患者血浆中游离sNS1水平高于DF患者。发病72小时内游离sNS1水平升高（大于或等于600 ng/mL）表明患者有发展DHF的风险。
Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (greater than or equal to600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF.