Mitigating head motion artifact in functional connectivity MRI.

Mitigating head motion artifact in functional connectivity MRI.
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DOI:
10.1038/s41596-018-0065-y
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发表时间:
2018-12
期刊:
影响因子:
14.8
通讯作者:
Satterthwaite TD
Satterthwaite TD
中科院分区:
生物学1区
文献类型:
--
作者:
Ciric R;Rosen AFG;Erus G;Cieslak M;Adebimpe A;Cook PA;Bassett DS;Davatzikos C;Wolf DH;Satterthwaite TD

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Participant motion during functional magnetic resonance image (fMRI) acquisition produces spurious signal fluctuations that can confound measures of functional connectivity. Without mitigation, motion artefact can bias statistical inferences about relationships between connectivity and individual differences. To counteract motion artefact, this protocol describes the implementation of a high-performance denoising strategy that combines a set of model features, including physiological signals, motion estimates, and mathematical expansions, to target both widespread and focal effects of subject movement. This method can reduce motion-related variance to near zero in studies of functional connectivity, providing up to a hundredfold improvement over minimal processing approaches in large data sets. Image denoising requires 40 minutes to 4 hours of computing per image, depending on model specifications and data dimensionality. The protocol additionally includes instructions for assessing the performance of a denoising strategy. Associated software implements all denoising and diagnostic procedures using a combination of established image processing libraries (FSL, AFNI, and ANTs) and new pipeline software (the XCP system, downloadable from Github: http://github.com/PennBBL/xcpEngine).
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