Methodological comparison of active- and passive-driven oscillations in blood pressure; implications for the assessment of cerebral pressure-flow relationships
Methodological comparison of active- and passive-driven oscillations in blood pressure; implications for the assessment of cerebral pressure-flow relationships
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DOI：
10.1152/japplphysiol.00264.2015
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发表时间：
2015-09-01
影响因子：
3.3
通讯作者：
Ainslie, Philip N.
中科院分区：
文献类型：
--
作者：
Smirl, Jonathan D.;Hoffman, Keegan;Ainslie, Philip N.
我们检查了主动（蹲立动作）和被动[振荡下半身负压（OLBNP）动作]驱动的血压波动的日间再现性。这些关系在较年轻（n = 10；25 +/- 3 岁）和较年长（n = 9；66 +/- 4 岁）成年人中进行了检查。每个测试方案都包含休息（5 分钟），然后以 0.05（5 分钟）和 0.10（5 分钟）Hz 的频率进行驱动操作，以增加血压变异性并使用线性传递函数分析改进对压力-流量动态的评估。监测逐次血压、大脑中动脉流速和呼气末二氧化碳分压。压力-流量关系在极低（0.02-0.07 Hz）和低（0.07-0.20 Hz）频率（LF；自发数据）以及0.05和0.10 Hz（驱动机动点估计）下进行量化。尽管不存在年龄间差异，但很少有自发性和 OLBNP 传递函数指标符合可接受的再现性标准，如日间、受试者内变异系数 (CoV) 所反映的那样
We examined the between-day reproducibility of active (squat-stand maneuvers)- and passive [oscillatory lower-body negative pressure (OLBNP) maneuvers]-driven oscillations in blood pressure. These relationships were examined in both younger (n = 10; 25 +/- 3 yr) and older (n = 9; 66 +/- 4 yr) adults. Each testing protocol incorporated rest (5 min), followed by driven maneuvers at 0.05 (5 min) and 0.10 (5 min) Hz to increase blood-pressure variability and improve assessment of the pressure-flow dynamics using linear transfer function analysis. Beat-to-beat blood pressure, middle cerebral artery velocity, and end-tidal partial pressure of CO2 were monitored. The pressure-flow relationship was quantified in the very low (0.02-0.07 Hz) and low (0.07-0.20 Hz) frequencies (LF; spontaneous data) and at 0.05 and 0.10 Hz (driven maneuvers point estimates). Although there were no between-age differences, very few spontaneous and OLBNP transfer function metrics met the criteria for acceptable reproducibility, as reflected in a between-day, within-subject coefficient of variation (CoV) of