Effect of e-Cigarette Use on Cough Reflex Sensitivity
Effect of e-Cigarette Use on Cough Reflex Sensitivity
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DOI：
10.1378/chest.15-0817
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发表时间：
2016-01-01
期刊：
影响因子：
9.6
通讯作者：
Negassa, Abdissa
中科院分区：
文献类型：
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作者：
Dicpinigaitis, Peter V.;Chang, Alfredo Lee;Negassa, Abdissa
背景：电子烟（e-cigs）已经广泛流行，但对其生理影响的了解仍然很少。本研究的目的是评估单次暴露于电子烟蒸汽对咳嗽反射sensitivity.METHODS的影响：三十名健康的非吸烟者进行咳嗽反射敏感性测量，使用辣椒素咳嗽挑战在基线，15分钟，24小时后电子烟曝光（30喷30秒间隔）。咳嗽激发的终点是诱导五次或更多次咳嗽的辣椒素浓度（C-5）。对每次吸入电子烟引起的咳嗽次数进行计数。一个亚组的受试者（n = 8）随后接受了相同的协议与不含尼古丁的电子烟。（C-5升高）电子烟使用后15分钟（-0.29; 95%CI，-0.43至-0.15; P < .0001）; 24小时后，C-5恢复至基线（0.24; 95%CI，0.10-0.38; P = .0002 vs 15分钟后值）。一个由8名受试者组成的亚组显示出最大程度的咳嗽反射抑制，在暴露于不含尼古丁的电子烟后没有抑制（P = 0.0078，用于比较尼古丁与非尼古丁装置后的Delta C-5）。此外，含尼古丁与不含尼古丁的设备引起更多的咳嗽（P = .0156）。结论：电子烟使用的单次会议，近似于一根烟草香烟的尼古丁暴露，引起咳嗽反射敏感性的显着抑制。对受试者亚组的探索性分析表明，尼古丁是导致该观察结果的原因。我们的数据，与以前的研究一致的尼古丁的影响，表明尼古丁的双重作用：立即，外周镇咳作用和延迟中枢镇咳作用。
BACKGROUND: E-cigarettes (e-cigs) have attained widespread popularity, yet knowledge of their physiologic effects remains minimal. The aim of this study was to evaluate the effect of a single exposure to e-cig vapor on cough reflex sensitivity.METHODS: Thirty healthy nonsmokers underwent cough reflex sensitivity measurement using capsaicin cough challenge at baseline, 15 min, and 24 h after e-cig exposure (30 puffs 30 s apart). The end point of cough challenge is the concentration of capsaicin inducing five or more coughs (C-5). The number of coughs induced by each e-cig inhalation was counted. A subgroup of subjects (n = 8) subsequently underwent an identical protocol with a non-nicotine-containing e-cig.RESULTS: Cough reflex sensitivity was significantly inhibited (C-5 increased) 15 min after e-cig use (-0.29; 95% CI, -0.43 to -0.15; P < .0001); 24 h later, C-5 returned to baseline (0.24; 95% CI, 0.10-0.38; P = .0002 vs post-15-min value). A subgroup of eight subjects demonstrating the largest degree of cough reflex inhibition had no suppression after exposure to a non-nicotine-containing e-cig (P = .0078 for comparison of Delta C-5 after nicotine vs non-nicotine device). Furthermore, more coughing was induced by the nicotine-containing vs non-nicotine-containing device (P = .0156).CONCLUSIONS: A single session of e-cig use, approximating nicotine exposure of one tobacco cigarette, induces significant inhibition of cough reflex sensitivity. Exploratory analysis of a subgroup of subjects suggests that nicotine is responsible for this observation. Our data, consistent with previous studies of nicotine effect, suggest a dual action of nicotine: an immediate, peripheral protussive effect and a delayed central antitussive effect.