LOCAL CEREBRAL GLUCOSE-METABOLISM DURING CONTROLLED HYPOXEMIA IN RATS
LOCAL CEREBRAL GLUCOSE-METABOLISM DURING CONTROLLED HYPOXEMIA IN RATS
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DOI：
10.1126/science.432667
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发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
DUFFY, TE
中科院分区：
文献类型：
--
作者：
PULSINELLI, WA;DUFFY, TE
用放射自显影术检查了缺氧、血压正常大鼠脑中2-脱氧-[14 C]葡萄糖代谢，发现高代谢和低代谢的皮质柱交替。白色物质的活性比邻近的灰质增加了几倍。这些柱在解剖学上与穿透皮质动脉相关，动脉之间的区域表现出更高的代谢率。存在影响局部葡萄糖代谢的动脉间组织O2梯度。白色物质代谢对缺氧的相对更大的敏感性可能导致对缺氧后白质脑病中白色物质损伤的理解。
2-Deoxy-[14C]glucose metabolism was examined in brains of hypoxic, normotensive rats by autoradiography, which revealed alternating cortical columns of high and low metabolism. Activity in white matter was increased severalfold over that in adjacent gray matter. The columns were anatomically related to penetrating cortical arteries with areas between arteries demonstrating higher rates of metabolism. The presence of interarterial tissue O2 gradients that influence regional glucose metabolism. The relatively greater sensitivity of white matter metabolism to hypoxia may lead to an understanding of white matter damage in postanoxic leukoencephalopathy.