Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy
Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy
复制标题
组织解剖中液体-组织界面周围残余空化气泡的时空超声成像
DOI：
10.1121/1.4919286
复制
发表时间：
2015-05-01
影响因子：
2.4
通讯作者：
Wan, Mingxi
中科院分区：
文献类型：
--
作者：
Hu, Hong;Xu, Shanshan;Wan, Mingxi
空化被认为是通过脉冲高强度聚焦超声进行软组织破碎（组织破碎术）的主要机制。残余空化气泡对组织破坏脉冲具有双重影响：这些气泡充当容易产生新空化的核，并且充当引起能量“遮蔽”的强散射体。“为了监测组织碎石术中残余空化气泡，本文提出了一种结合平面波传输、最小方差波束形成和相干因子加权的超快主动空化成像方法，该方法具有较高的信噪比和良好的时空分辨率。用该方法监测了在10-40 μ s脉冲宽度（PD）和0.67 ~ 2kHz脉冲重复频率（PRF）条件下，组织破坏过程中液体-组织界面周围残余空化气泡的时空演变。从气泡图像序列中获得组织界面内的积分气泡面积曲线，并估计组织破坏损伤的形成过程。观察到组织破坏效率随着PD更长和PRF更高而降低。组织破坏面积与内部残留气泡面积之间存在正相关关系，相关系数为1.0365，为进一步监测和优化组织破坏治疗提供了依据。(C)2015年美国声学学会。
Cavitation is considered as the primary mechanism of soft tissue fragmentation (histotripsy) by pulsed high-intensity focused ultrasound. The residual cavitation bubbles have a dual influence on the histotripsy pulses: these serve as nuclei for easy generation of new cavitation, and act as strong scatterers causing energy "shadowing." To monitor the residual cavitation bubbles in histotripsy, an ultrafast active cavitation imaging method with relatively high signal-to-noise ratio and good spatial-temporal resolution was proposed in this paper, which combined plane wave transmission, minimum variance beamforming, and coherence factor weighting. The spatial-temporal evolutions of residual cavitation bubbles around a fluid-tissue interface in histotripsy under pulse duration (PD) of 10-40 mu s and pulse repetition frequency (PRF) of 0.67-2 kHz were monitored by this method. The integrated bubble area curves inside the tissue interface were acquired from the bubble image sequence, and the formation process of histotripsy damage was estimated. It was observed that the histotripsy efficiency decreased with both longer PDs and higher PRFs. A direct relationship with a coefficient of 1.0365 between histotripsy lesion area and inner residual bubble area was found. These results can assist in monitoring and optimization of the histotripsy treatment further. (C) 2015 Acoustical Society of America.