Brain imaging of sequential acquisition using a flexible PET scanner and 3-T MRI: quantitative and qualitative assessment
Brain imaging of sequential acquisition using a flexible PET scanner and 3-T MRI: quantitative and qualitative assessment
复制标题
使用灵活的 PET 扫描仪和 3-T MRI 进行顺序采集的脑成像：定量和定性评估
DOI：
10.1007/s12149-022-01817-6
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发表时间：
2022
影响因子：
2.6
通讯作者：
Nakamoto Yuji
中科院分区：
文献类型：
--
作者：
Nakajima Satoshi;Fushimi Yasutaka;Hinoda Takuya;Sakata Akihiko;Okuchi Sachi;Arakawa Yoshiki;Ishimori Takayoshi;Nakamoto Yuji
被称为柔性PET（fxPET）的移动的PET扫描仪已经被设计成适合现有的MRI系统。本研究的目的是评估与传统的PET（cPET）/CT.MethodsIn这项前瞻性研究中，29例受试者没有可见的病变，除了轻度脑白质疏松症的全脑成像2-脱氧-2-[18 F]氟-D-葡萄糖（[18 F]FDG）cPET/CT，然后fxPET和MRI的fxPET/CT结合脑成像与3-T MRI。通过测量空间坐标比较fxPET与MRI、cPET与CT之间的配准差异。磁共振三维快速采集梯度回波T1加权成像（T1 WI）。我们对fxPET图像应用了两种衰减校正方法：基于MR的衰减校正，产生fxPETMRAC;基于CT的衰减校正，产生fxPETCTAC。将三个PET数据集共配准到T1 WI。在皮质下分割和皮质包裹后，将感兴趣的体积放置在每个PET图像中以评估大脑中的生理积累。得到了三个数据集之间的SUV均值并进行了比较。我们还直观地评估了图像失真和清晰度fxPETMRAC.ResultsMean misregistration fxPET/MRI是< 3毫米的每个边缘。fxPET/MRI的平均配准差异显著大于cPET/CT，但上级边缘除外。关于SUV平均值，三个PET数据集之间存在高度相关性。在视觉评价图像质量，失真的等级是可比fxPETMRAC和cPET之间，和清晰度的等级是可以接受的，但较差的fxPETMRAC相比cPET.ConclusionsfxPET可以成功地确定生理[18 F]FDG摄取，但是，提高图像清晰度是可取的。在这项研究中，3-T的fxPET/MRI用于脑成像是可行的。
ObjectiveA mobile PET scanner termed flexible PET (fxPET) has been designed to fit existing MRI systems. The purpose of this study was to assess brain imaging with fxPET combined with 3-T MRI in comparison with conventional PET (cPET)/CT.MethodsIn this prospective study, 29 subjects with no visible lesions except for mild leukoaraiosis on whole brain imaging underwent 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) cPET/CT followed by fxPET and MRI. The registration differences between fxPET and MRI and between cPET and CT were compared by measuring spatial coordinates. Three-dimensional magnetization-prepared rapid acquisition gradient-echo T1-weighted imaging (T1WI) was acquired. We applied two methods of attenuation correction to the fxPET images: MR-based attenuation correction, which yielded fxPETMRAC; and CT-based attenuation correction, which yielded fxPETCTAC. The three PET datasets were co-registered to the T1WI. Following subcortical segmentation and cortical parcellation, volumes of interest were placed in each PET image to assess physiological accumulation in the brain. SUVmeanwas obtained and compared between the three datasets. We also visually evaluated image distortion and clarity of fxPETMRAC.ResultsMean misregistration of fxPET/MRI was < 3 mm for each margin. Mean registration differences were significantly larger for fxPET/MRI than for cPET/CT except for the superior margin. There were high correlations between the three PET datasets regarding SUVmean. On visual evaluation of image quality, the grade of distortion was comparable between fxPETMRACand cPET, and the grade of clarity was acceptable but inferior for fxPETMRACcompared with cPET.ConclusionsfxPET could successfully determine physiological [18F]FDG uptake; however, improved image clarity is desirable. In this study, fxPET/MRI at 3-T was feasible for brain imaging.