X-chromosome inactivation: a repeat hypothesis
X-chromosome inactivation: a repeat hypothesis
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DOI：
10.1159/000014969
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Lyon, MF
中科院分区：
文献类型：
--
作者：
Lyon, MF
最近的研究表明，X染色体的失活是由包裹在非活性X染色体上的Xist mRNA引起的。本文对该RNA的功能提出了一个假说。我们认为，X染色体特别丰富的线型穿插重复元件可作为促进Xist基因传播的助推器元件。与这种核糖核酸的接触会使线状元件被细胞系统感知为重复元件，从而导致重复诱导的基因沉默。这导致这些元件和通过它们转换成异染色质而介入的独特序列的沉默。
Recent work has shown that X-chromosome inactivation is brought about by Xist mRNA, which coats the inactive X-chromosome. This paper presents a hypothesis on the function of this RNA. It is suggested that interspersed repetitive elements of the LINE type, in which the X-chromosome is particularly rich, act as booster elements to promote the spread of Xist mRNA. Contact with this RNA causes the LINE elements to be sensed as repeated elements by the cell's system for repeat-induced gene silencing. This leads to the silencing of these elements and the intervening unique sequences by their conversion to heterochromatin.