Donepezil in the treatment of musical hallucinations
Donepezil in the treatment of musical hallucinations
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DOI：
10.1111/j.1440-1819.2007.01636.x
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发表时间：
2007-04-01
影响因子：
11.9
通讯作者：
Takeda, Masatoshi
中科院分区：
文献类型：
--
作者：
Ukai, Satoshi;Yamamoto, Masakiyo;Takeda, Masatoshi
音乐幻觉（MH）通常发生在老年人中，并与听力障碍有关。作者描述了一位具有典型MH特征的患者，他成功地用多奈哌齐（一种胆碱酯酶抑制剂）作为联合治疗，并且在大约5年内没有表现出任何随后的认知能力下降。多奈哌齐在该患者中的疗效提示，胆碱能神经元的年龄依赖性功能障碍可能与MH的发生有关。
Musical hallucinations (MH) typically occur among elderly individuals and are associated with hearing impairment. The authors describe a patient with features of typical MH who was successfully treated with donepezil, a cholinesterase inhibitor, as a combination therapy and who has not shown any subsequent cognitive decline for approximately 5 years. The efficacy of donepezil in this patient indicates that age-dependent dysfunction of cholinergic neurons might be related to the development of MH.