Cortical 6-[18F]fluoro-L-dopa uptake and frontal cognitive functions in early Parkinson's disease
Cortical 6-[18F]fluoro-L-dopa uptake and frontal cognitive functions in early Parkinson's disease
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DOI：
10.1016/j.neurobiolaging.2004.07.014
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发表时间：
2005-06-01
影响因子：
4.2
通讯作者：
Rinne, JO
中科院分区：
文献类型：
--
作者：
Brück, A;Aalto, S;Rinne, JO
帕金森氏病(PD)患者在疾病的早期阶段就已经损害了表现，特别是在测试额叶功能时，如注意力。这些缺陷的病理生理学基础尚不清楚。本研究对21例非痴呆、非药物治疗的帕金森病早期患者和24例健康对照进行正电子发射断层扫描，以6[F-18]氟-L-多巴为示踪剂。此外，帕金森病患者还进行了一系列神经心理测试，包括测量持续注意力(VIG)和需要抑制注意力的测试(Stroop)。使用了基于体素的统计参数映射(SPM)和自动感兴趣区(ROI)分析。与对照组相比，帕金森病患者纹状体FDOPA摄取减少，大脑皮层FDOPA摄取增加。VIG测试的反应时间与前额叶背外侧皮质的FDOPA摄取呈正相关，Stroop测试的成绩与额叶内侧皮质和前扣带回的FDOPA摄取呈负相关。结果显示，非药物治疗的早期帕金森病患者大脑皮质FDOPA摄取增加，提示额叶FDOPA摄取的改变与早期帕金森病患者的认知损害有关。(C)2004 Elsevier Inc.保留所有权利。
yPatients with Parkinson's disease (PD) have already at the early stages of the disease impaired performance especially in tests measuring frontal lobe functions such as attention. The pathophysiological basis of these deficits is unclear. In the present study, 21 non-demented, non-medicated patients at the early stage of PD and 24 healthy controls underwent a positron emission tomography (PET) scan with 6[F-18]fluoro-L-dopa (Fdopa) as the tracer. In addition, the PD patients performed a neuropsychological test battery, including a test measuring sustained attention (VIG) and a test requiring suppressed attention (Stroop). Both voxel-based Statistical Parametric Mapping (SPM) and automated region of interest (ROI) analysis were employed. Compared to controls, the PD patients had decreased Fdopa uptake in the striatum and a large cortical area of increased Fdopa uptake. The reaction time in the VIG test correlated positively with the Fdopa uptake of the dorsolateral prefrontal cortex and the performance in the Stroop test correlated negatively with the Fdopa uptake in an area including the medial frontal cortex and the anterior cingulate. The results show that cortical Fdopa uptake is increased in early non-medicated PD and suggest that the changes in frontal Fdopa uptake are related to cognitive impairments found in early PD. (c) 2004 Elsevier Inc. All rights reserved.