An N-heterocyclic carbene ligand with flexible steric bulk allows Suzuki cross-coupling of sterically hindered aryl chlorides at room temperature
An N-heterocyclic carbene ligand with flexible steric bulk allows Suzuki cross-coupling of sterically hindered aryl chlorides at room temperature
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DOI：
10.1002/anie.200351325
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Glorius, F
中科院分区：
文献类型：
--
作者：
Altenhoff, G;Goddard, R;Glorius, F
一个杂耍行为：配体的空间体积增强了Pd催化的Suzuki交叉偶联中的还原消除。然而，它阻碍了空间位阻底物的氧化加成和代谢。这种困境是解决与卡宾配体1，它表现出灵活的空间体积。
A juggling act: The steric bulk of the ligand enhances reductive elimination in the Pd‐catalyzed Suzuki cross‐coupling. However, it impedes the oxidative addition and transmetallation of sterically hindered substrates. This dilemma is solved with the carbene ligand 1, which exhibits flexible steric bulk.