Thalassaemia in a Gurkha Family
Thalassaemia in a Gurkha Family
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廓尔喀家族的地中海贫血
DOI：
10.1136/bmj.1.5187.1711
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发表时间：
1960
影响因子：
--
通讯作者：
F. Vella
中科院分区：
文献类型：
--
作者：
D. Weatherall;F. Vella
病例中，但注意发生子宫内膜癌的病例有较长的历史。Kaufman等人（1959）发现子宫内膜增生的发生率较高，与我们的研究结果一致。因此，可能建议在某些病例中诊断为出血性血液病。然而，典型的出血性血液病患者闭经时间不会超过3个月。在这家医院，囊性腺体增生的发现比以前怀疑的要多，它可能发生在月经规律的患者身上。它有时与黄体有关，在子宫内可见囊性腺体增生。引用的早期和更大的一系列病例似乎没有进行常规子宫内膜活检，可能更多的病例会显示这种组织学图片。第一组的楔形切除结果显示，除了两名分别在手术后2年和3年怀孕的妇女外，正常月经没有持续超过6个月。在排卵组2中，随访的6例患者中，有2例月经正常超过1年。1例患者正常月经6个月后复发为闭经。另外三名患者在四个月后仍有规律的月经，但没有更长的随访。Stein（1958）报告95%的患者月经恢复正常，其中88%的患者怀孕。
cases, but noted the occurrence of endometrial carcinoma in cases with long histories. Kaufman et al. (1959) found a higher incidence of endometrial hyperplasia, as we have done. It may be suggested that the diagnosis in some of these cases should therefore be metropathia haemorrhagica. However, typical cases of metropathia haemorrhagica do not have periods of amenorrhoea lasting longer than three months. At this hospital cystic glandular hyperplasia is found more often than was formerly suspected, and it may occur in patients who are menstruating regularly. It is sometimes found in association with corpora lutea, and pregnancy has been seen to occur in a uterus which showed cystic glandular hyperplasia. The earlier and larger series of cases quoted do not appear to have had routine endometrial biopsies taken, and it is possible that many more would have shown this histological picture. The results of wedge resection in group 1 show that regular menstruation has not persisted for longer than six months, with the exception of two women who became pregnant two and three years respectively after operation. In group 2, where ovulation was occurring, of the six patients followed up, two had menstruated normally for more than a year. Regular menstrual periods had occurred in one patient for six months, but after this time she relapsed into amenorrhoea. The other three patients were still menstruating regularly at the end of four months, but a longer follow-up is not available. Stein (1958) has reported re-establishment of normal menstruation in 95% of patients, and 88% of his cases became pregnant.