Adaptation to conflict via context-driven anticipatory signals in the dorsomedial prefrontal cortex.
Adaptation to conflict via context-driven anticipatory signals in the dorsomedial prefrontal cortex.
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DOI：
10.1523/jneurosci.2783-11.2011
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发表时间：
2011-11-09
期刊：
影响因子：
--
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Horga G;Maia TV;Wang P;Wang Z;Marsh R;Peterson BS
Behavioral interference elicited by competing response tendencies adapts to contextual changes. Recent nonhuman primate research suggests a key mnemonic role of distinct prefrontal cells in supporting such context-driven behavioral adjustments by maintaining conflict information across trials, but corresponding prefrontal functions have yet to be probed in humans. Using event-related functional magnetic resonance imaging (fMRI), we investigated the human neural substrates of contextual adaptations to conflict. We found that a neural system comprising the rostral dorsomedial prefrontal cortex and portions of the dorsolateral prefrontal cortex specifically encodes the history of previously experienced conflict and influences subsequent adaptation to conflict on a trial-by-trial basis. This neural system became active in anticipation of stimulus onsets during preparatory periods and interacted with a second neural system engaged during the processing of conflict. Our findings suggest that a dynamic interaction between a system that represents conflict history and a system that resolves conflict underlies the contextual adaptation to conflict.
