PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in postmenopausal Japanese women
PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in postmenopausal Japanese women
复制标题
日本绝经后女性PPARγ基因多态性、C反应蛋白水平、BMI与牙周炎
作者：
Wang Y;Sugita N;Yoshihara A;Iwasaki M;Miyazaki H;Nakamura K;Yoshie H
背景关于PPARγPro12Ala基因多态性与肥胖之间的关系，已有几项研究报道了不一致的结果。肥胖者C反应蛋白水平高于正常体重者，激活PPARγ可显著降低血清高敏C反应蛋白水平。目的研究日本绝经后妇女PPARγ基因多态性与血清C反应蛋白水平、体重指数和/或牙周炎的关系。测量每颗牙的牙周参数，包括PD、CAL和BOP。用聚合酶链式反应-限制性片段长度多态性方法检测γ的Pro12Ala基因。用乳胶散射比浊法测定Hs-CRP值。结果不同基因型之间年龄、BMI和牙周参数无显著差异。HsCRP+≥+1 mg/L组PD、≥>4 mm的部位百分比显著高于hsCRP+1 mg/L组(p=0.003)。在PPARALA等位基因携带者中，血清hsCRP水平与PD、≥<4 mm的部位百分比呈正相关(p=0.0.043)，在非携带者中与γ呈正相关(p=0.0.033)。结论日本绝经后妇女PPARγPro12Ala基因多态性与牙周炎、血清C反应蛋白水平及体重指数无独立关联。但在ALA等位基因携带者中，血清hsCRP水平与牙周炎相关，在非携带者中，血清hsCRP水平与BMI相关。
BackgroundSeveral studies have reported inconsistent results regarding the association between the PPARγPro12Ala polymorphism and obesity. Obese individuals had higher C‐reactive protein (CRP) levels compared with those of normal weight, and PPARγ activation could significantly reduce serum high‐sensitive CRP level. We have previously suggested that the Pro12Ala polymorphism represents a susceptibility factor for periodontitis, which is a known risk factor for increased CRP level.ObjectivesThe aim was to investigate associations between PPARγ gene polymorphism, serum CRP level, BMI and/or periodontitis among post‐menopausal Japanese women.Materials and methodsThe final sample in this study comprised 359 post‐menopausal Japanese women. Periodontal parameters, including PD, CAL and BOP, were measured per tooth. PPARγPro12Ala genotype was determined by PCR‐RFLP. Hs‐CRP value was measured by a latex nephelometry assay.ResultsNo significant differences in age, BMI or periodontal parameters were found between the genotypes. The percentages of sites with PD ≥ 4 mm were significantly higher among the hsCRP ≥ 1 mg/l group than the hsCRP < 1 mg/l group (p= 0.003). Positive correlations were found between serum hsCRP levels and the percentages of sites with PD ≥ 4 mm (p= 0.043) in PPARγ Ala allele carriers, and BMI (p= 0.033) in non‐carriers. After adjustment for model covariates, BMI was significantly associated with serum hsCRP level.ConclusionThe PPARγPro12Ala polymorphism was not independently associated with periodontitis, serum CRP level or BMI in post‐menopausal Japanese women. However, serum hsCRP level correlated with periodontitis in Ala allele carriers, and with BMI in non‐carriers.