Human endometrial adenocarcinoma transplanted into nude mice: growth regulation by estradiol.
Human endometrial adenocarcinoma transplanted into nude mice: growth regulation by estradiol.
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人子宫内膜腺癌移植到裸鼠体内：雌二醇对生长的调节。
DOI：
10.1126/science.6849115
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发表时间：
1983
期刊：
影响因子：
56.9
通讯作者：
R. Mortel
中科院分区：
文献类型：
--
作者：
P. Satyaswaroop;R. Zaino;R. Mortel
以去卵巢裸鼠为受体，建立了研究人子宫内膜原发性肿瘤生长及17 β-雌二醇对其调节作用的模型。性类固醇的受体在该系统中的肿瘤的连续移植期间维持。尽管移植到卵巢切除裸鼠中的受体阴性子宫内膜肿瘤的生长速率不受持续存在或不存在雌二醇的影响，但受体阳性肿瘤的生长显著增加雌二醇。受体阳性肿瘤用雌二醇治疗产生升高的孕激素受体浓度。孕激素受体在该肿瘤中起作用，这一点可从给药后雌二醇17 β-脱氢酶活性的诱导中得到证实。这些发现与受体介导的子宫内膜癌生长调节一致。
A model for studying the growth of primary tumors of human endometrium and its regulation by 17 beta-estradiol has been developed in which ovariectomized nude mice are used as recipients. The receptors for sex steroids are maintained during serial transplantation of the tumor in this system. Although the rate of growth of receptor-negative endometrial tumors transplanted into ovariectomized nude mice is unaffected by the sustained presence or absence of estradiol, the growth of receptor-positive tumors is significantly increased by estradiol. Receptor-positive tumors treated with estradiol produced elevated concentrations of progesterone receptor. That the progesterone receptor is functional in this tumor is evident from the induction of estradiol 17 beta-dehydrogenase activity upon progestin administration. These findings are consistent with receptor-mediated regulation of growth of endometrial carcinoma.