Enhancing the interaction between annexin-1 and formyl peptide receptors regulates microglial activation to protect neurons from ischemia-like injury
Enhancing the interaction between annexin-1 and formyl peptide receptors regulates microglial activation to protect neurons from ischemia-like injury
复制标题
增强annexin-1和甲酰肽受体之间的相互作用调节小胶质细胞活化以保护神经元免受缺血样损伤
DOI：
10.1016/j.jneuroim.2014.07.013
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发表时间：
2014-11-15
影响因子：
3.3
通讯作者：
Shi, Jing
中科院分区：
文献类型：
--
作者：
Luo, Zhen Zhao;Gao, Yan;Shi, Jing
小胶质细胞作为大脑的免疫细胞，对维持大脑功能起着至关重要的作用。本研究的目的是确定膜联蛋白-1是否以及如何影响病变微环境中的小胶质细胞表型和迁移。在本实验中，我们增强了小胶质细胞中膜联蛋白-1与甲酰基肽受体的相互作用，并分析了其功能。我们发现膜联蛋白-1可以使小胶质细胞极化为有益表型，促进小胶质细胞迁移，保护神经元免受缺血样损伤，膜联蛋白-1介导的神经保护作用依赖于受损神经元释放谷氨酸和ATP。(C) 2014 Elsevier B.V.版权所有
As the immune cells of the brain, microglia are crucial for the maintenance of brain function. The aims of the present study were to determine whether and how annexin-1 is able to affect microglial phenotype and migration in the lesion microenvironment. In the current experiment, we enhanced the interaction between annexin-1 and formyl peptide receptors in microglia and analyzed the function. We found that annexin-1 could polarize microglia to a beneficial phenotype and promote microglial migration to protect neurons from ischemia-like injury, and the annexin-l-mediated neuroprotective effect was dependent on the release of glutamate and ATP from the injured neurons. (C) 2014 Elsevier B.V. All rights reserved.