Parkinson's syndrome after closed head injury: a single case report
Parkinson's syndrome after closed head injury: a single case report
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DOI：
10.1136/jnnp.66.3.380
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发表时间：
1999-03-01
影响因子：
11
通讯作者：
Lees, AJ
中科院分区：
文献类型：
--
作者：
Doder, M;Jahanshahi, M;Lees, AJ
一名36岁的男子，在1984年遭受颅骨骨折，昏迷24小时，并在受伤后6周出现帕金森综合征的迹象。在1995年进行评估时，神经影像学检查显示，由于左侧尾状核和豆状核的创伤导致脑梗死。帕金森综合征主要是右侧，缓慢进展，对左旋多巴治疗无反应。反应时间测试显示双手，特别是右手的动作启动和执行缓慢。记录运动相关的皮层电位表明，在运动准备的双边赤字。神经心理学评估显示，没有证据表明执行功能或工作记忆测试中存在重大缺陷，但Stroop和自序随机数序列测试中存在选择性损伤。有精神障碍的迹象。结果进行了讨论，与以前的文献基底神经节病变和损害的影响，不同点的额纹状体电路。
A 36 year old man, who sustained a skull fracture in 1984, was unconscious for 24 hours, and developed signs of Parkinson's syndrome 6 weeks after the injury. When assessed in 1995, neuroimaging disclosed a cerebral infarction due to trauma involving the left caudate and lenticular nucleus. Parkinson's syndrome was predominantly right sided, slowly progressive, and unresponsive to levodopa therapy. Reaction time tests showed slowness of movement initiation and execution with both hands, particularly the right. Recording of movement related cortical potentials suggested bilateral deficits in movement preparation. Neuropsychological assessment disclosed no evidence of major deficits on tests assessing executive function or working memory, with the exception of selective impairments on the Stroop and on a test of self ordered random number sequences. There was evidence of abulia. The results are discussed in relation to previous literature on basal ganglia lesions and the effects of damage to different points of the frontostriatal circuits.