Tooth regeneration: Implications for the use of bioengineered organs in first-wave organ replacement
Tooth regeneration: Implications for the use of bioengineered organs in first-wave organ replacement
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DOI：
10.1111/j.1749-0774.2007.00031.x
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发表时间：
2007-08
期刊：
影响因子：
4.3
通讯作者：
T. Nakahara;Y. Ide
中科院分区：
文献类型：
--
作者：
T. Nakahara;Y. Ide
动物模型实验表明，使用将牙蕾细胞和可生物降解材料相结合的组织工程技术，或使用胚胎组织和成人干细胞，可以再生牙冠结构。此外，通过移植牙齿干细胞重建了牙根和牙周组织，导致了牙齿功能的恢复，这表明在不久的将来，人类的牙齿再生将成为可能。本文综述了牙齿再生的研究现状，讨论了一种可用于临床的牙齿再生模型，并提出了一种新的牙齿再生方法，克服了牙齿替换模型的困难。牙齿再生是建立工程化器官移植的重要基石，而工程化器官移植是再生治疗的最终目标之一。
Experiments with animal models have shown that the tooth crown structure can be regenerated using tissue engineering techniques that combine tooth bud cells and biodegradable materials, or by using embryonic tissue and adult stem cells. Moreover, tooth roots and periodontal tissues have been reconstructed by grafting dental stem cells, which leads to the recovery of tooth function, suggesting that tooth regeneration will become possible in humans in the near future. The present article reviews current research on tooth regeneration, discusses a model of tooth replacement that could be used clinically, and proposes a new tooth regeneration approach that overcomes the difficulties associated with the tooth replacement model. Tooth regeneration is an important stepping stone in the establishment of engineered organ transplantation, which is one of the ultimate goals of regenerative therapies.