A Method for the 12‐Hour Evaluation of Analgesic Efficacy in Outpatients with Postoperative Oral Surgery Pain
A Method for the 12‐Hour Evaluation of Analgesic Efficacy in Outpatients with Postoperative Oral Surgery Pain
复制标题
口腔手术后疼痛门诊患者12小时镇痛效果评价方法
作者：
W. Beaver;J. Forbes;R. Shackleford
我们开发了一种方法，用于测量口腔手术后疼痛门诊患者服用单剂量镇痛药 12 小时后的疗效。患者使用自我评分记录来评估用药后 12 小时内的疼痛及其缓解情况。我们已在一系列三项研究中成功地使用这种方法来比较二氟尼柳（一种新型非甾体类抗炎镇痛药）与安慰剂和阿司匹林 650 mg、对乙酰氨基酚 600 mg、萘磺酸丙氧芬 100 mg 或对乙酰氨基酚与可待因 60 mg 或丙氧芬 100 mg 的组合。二氟尼柳表现出异常长的镇痛作用持续时间。在每项研究中，在 12 小时观察期结束时，所有剂量的二氟尼柳均显着优于安慰剂，而标准在 2 至 7 小时的观察期中均优于安慰剂。就镇痛峰值而言，二氟尼柳 1,000 mg 与对乙酰氨基酚-可待因组合相当，并且显着优于所有其他镇痛标准。
We have developed a method for measuring the efficacy of a single dose of an analgesic for 12 hours after administration to outpatients with postoperative oral surgery pain. Using a self‐rating record, patients evaluate their pain and its relief for 12 hours after medication. We have used this method successfully in a series of three studies to compare diflunisal, a new nonsteroidal antiinflammatory analgesic, with placebo and aspirin 650 mg, acetaminophen 600 mg, propoxyphene napsylate 100 mg, or a combination of acetaminophen with either codeine 60 mg or propoxyphene 100 mg. Diflunisal evinced an unusually long duration of analgesic effect. In each study, all doses of diflunisal were significantly superior to placebo through the end of the 12‐hour observation period, while the standards were superior for periods ranging from 2 to 7 hours. In terms of peak analgesia, diflunisal 1,000 mg was comparable to the acetaminophen‐codeine combination and was significantly superior to all the other analgesic standards.