SUBCUTANEOUS ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA
SUBCUTANEOUS ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA
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DOI：
10.1111/j.1365-2133.1969.tb15914.x
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发表时间：
1969-01-01
影响因子：
10.3
通讯作者：
WHIMSTER, IW
中科院分区：
文献类型：
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作者：
WELLS, GC;WHIMSTER, IW
报告9例头颈部持续性皮下结节，其组织学特征为血管淋巴样增生伴嗜酸性粒细胞增多症。他们都是年轻人，有一个或多个皮损，范围从1到10厘米。在直径上。除血嗜酸性粒细胞增多外，无全身性表现。虽然有些病变持续了几年，但这种情况似乎是良性的。结节主要位于皮下，但有时会延伸到覆盖的真皮，并深入肌肉或筋膜。它们是由无包膜的血管淋巴样增生性肿块组成，包括以下成分：1.毛细血管旺盛的增殖，常伴有不完全管状的内皮肿块。大量嗜酸性粒细胞浸润，肥大细胞增多。网状蛋白形成，少量胶原纤维形成。淋巴网状增生，随着皮损持续时间的延长而增加，并导致一年或一年以上的皮损中淋巴滤泡的形成。临床和组织学特征表明，有足够的共同基础将皮下血管淋巴样增生伴嗜酸性粒细胞增多视为一种独特的病理实体。讨论了它与日本描述的木村氏病的关系。
Persistent subcutaneous nodules on the head and neck with distinctive histological features of angiolymphoid hyperplasia with eosinophilia are reported in nine patients. They were all young adults and had one or more lesions ranging from 1 to 10 cm. in diameter. Apart from blood eosinophilia, there were no systemic manifestations. While some lesions persisted for several years, the condition appears to be benign. The nodules lie mainly in the sub‐cutis but sometimes extend into the overlying dermis and deeply into muscle or fascia. They are composed of unencapsulated masses of angiolymphoid hyperplasia with the following components:1. Exuberant proliferation of capillary vessels, often with imperfectly canalized masses of endothelium.2. Massive infiltration with eosinophils and an excess of mast cells.3. Reticulin formation but little collagenous fibrosis.4. Lymphoreticular hyperplasia, increasing with the duration of the lesion and leading to lymphoid follicle formation in lesions of one year or more duration.The clinical and histological features suggest enough common ground for regarding subcutaneous angiolymphoid hyperplasia with eosinophilia as a distinct pathological entity. Its relation to Kimura's disease as described in Japan is discussed.