Body distribution profile of polysaccharides after intravenous administration
Body distribution profile of polysaccharides after intravenous administration
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DOI：
10.3109/10717549309031345
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发表时间：
1993
期刊：
影响因子：
6
通讯作者：
T. Yamaoka;Y. Tabata;Y. Ikada
中科院分区：
文献类型：
--
作者：
T. Yamaoka;Y. Tabata;Y. Ikada
摘要研究了非离子型多糖普鲁兰多糖和右旋糖酐在小鼠体内的分布。用~（125）I标记的不同分子量的多糖静脉注射后，观察其在血液循环中的半衰期和体内分布，并与聚乙二醇（PEG）和聚乙烯醇（PVA）进行比较。高分子量的多糖在血液中循环的时间比低分子量的多糖长。普鲁兰多糖的半衰期为15 ~ 90 min，在分子量30，000左右变化，比右旋糖酐的半衰期短。身体分布的研究表明，普鲁兰多糖往往在肝脏中积累到更大的程度比葡聚糖，而PEG和PVA几乎没有处置。在研究的整个分子量范围内，观察到肝脏中多糖的这种优选积累。80%的大分子量普鲁兰多糖具有良好的生物活性。
AbstractThe body distribution of pullulan and dextran, which are nonionic polysaccharides, was studied. After intravenous injection of 125I-labeled polysaccharides with different molecular weights, the half-life period in the blood circulation and the body distribution were pharmacokinetically investigated and compared with those of polyethylene glycol (PEG) and polyvinyl alcohol (PVA). Polysaccharides of higher molecular weights circulated in the bloodstream for a longer period than those of lower molecular weights. The half-life period of pullulan ranged from 15 to 90 min, changing remark-ably around molecular weight 30,000, and was shorter than that of dextran. Body distribution studies demonstrated that pullulan tended to accumulate in the liver to a greater extent than dextran, whereas PEG and PVA were hardly disposed there. This preferable accumulation of polysaccharides in the liver was observed over the whole molecular weight range studied. Eighty percent of pullulan with large molecular weights w...