Episode sensitivity in association with process indicators in the Finnish breast cancer screening program
Episode sensitivity in association with process indicators in the Finnish breast cancer screening program
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DOI：
10.1002/ijc.21310
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发表时间：
2006-01-01
影响因子：
6.4
通讯作者：
Anttila, A
中科院分区：
文献类型：
--
作者：
Sarkeala, T;Hakama, M;Anttila, A
我们评估了芬兰乳腺X线摄影计划对50-59岁（部分为60-64岁）女性的事件敏感性，并探讨了1991年至1999年事件敏感性与筛查过程指标之间的关联。在研究期间，可从10个筛选中心获得数据。从1991年至2001年，721 000次筛查访问的记录与芬兰全国癌症登记处的个人档案相关联。在第一次和随后的筛查中计算筛查检出率和间隔期乳腺癌率。通过将间隔期癌症的发病率与未进行筛查的预期人群发病率（发病率方法）以及间隔期癌症在所有检测到的癌症中的比例（检测方法）进行比较，确定发作敏感性。在随后的筛选中，通过发生率方法确定的发作敏感性为54%，通过检测方法确定的发作敏感性为65%。筛查后0-11个月和12-23个月的敏感性分别为70%和38%。发作敏感性在研究期结束时降低，并随年龄增长而增加。召回率每绝对增加1%，中心特异性灵敏度增加13%。总的来说，我们的研究提供了关于筛查计划有效性的进一步信息。敏感性估计值与其他欧洲服务筛查计划的敏感性估计值相当。发作敏感性的变异性表明未来筛选结果可能存在变异。(c)2005年威利-利斯。Inc.
We assessed the episode sensitivity of the Finnish mammography program for women aged 50-59 (partly 60-64) years and explored associations between the episode sensitivity and the screening process indicators from 1991 to 1999. For the study period, data were available from 10 screening centers. Records of 721,000 screening visits were linked to the files of the nationwide Finnish Cancer Registry from 1991 to 2001 at an individual level. The rates of screen-detected and interval breast cancers were calculated at the first and at the subsequent screens. The episode sensitivity was determined by contrasting the incidence of interval cancers with the expected population incidence rate without screening (incidence method) and as a proportion of interval cancers out of all cancers detected (detection method). At the subsequent screens, the episode sensitivity determined by the incidence method was 54% and by the detection method 65%. The sensitivity 0-11 and 12-23 months after the screening was 70% and 38%, respectively. The episode sensitivity decreased toward the end of the study period and increased with age. The center-specific sensitivity increased 13% per 1% absolute increase in the recall rate. In general, our study provides further information on the effectiveness of screening programs. The sensitivity estimates were comparable with those from other European service screening programs. The variability in the episode sensitivity suggests potential for variations in the future screening outcome. (c) 2005 Wiley-Liss. Inc.