Functional mapping of human sensorimotor cortex with 3D BOLD fMRI correlates highly with (H2O)-O-15 PET rCBF
Functional mapping of human sensorimotor cortex with 3D BOLD fMRI correlates highly with (H2O)-O-15 PET rCBF
复制标题
DOI：
10.1097/00004647-199609000-00001
复制
发表时间：
1996-09-01
影响因子：
6.3
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Ramsey, NF;Kirkby, BS;Weinberger, DR
正电子发射断层扫描（PET）功能成像是基于区域脑血流量（rCBF）的变化。功能磁共振成像（fMRI）是基于多种生理参数以及rCBF。本研究旨在将对血氧变化敏感的三维（3D）功能磁共振成像与氧-15标记水（(H2O)-O-15） PET进行交叉验证。9名正常受试者在fMRI扫描和PET扫描期间反复执行简单的手指对立任务。受试者内部统计分析显示，在所有fMRI和PET测试的受试者中，对侧初级感觉运动皮层（PSM）的信号变化显著（“激活”）（p < 0.05， Bonferroni校正体素数）。通过这两种方法，78%的激活体素都位于PSM中。所有受试者都出现了重叠的激活区域（平均43%，标准差26%）。两种方法的PSM激活区大小高度相关（rho = 0.87, p < 0.01）。fMRI与PET对比，PSM活化区质心之间的平均距离为6.7 mm （SD 3.0 mm）。该区域激活体素中信号变化的平均幅度（用适应时间序列的z值z(t)表示）相似（fMRI 5.5, PET 5.3）。结果表明，利用3D回波移位原理与观察序列（PRESTO）功能磁共振成像（fMRI）获得的血氧水平依赖阳性（BOLD）信号变化与rCBF相关，fMRI的灵敏度可与(H2SO)-S-15 PET相当。
Positron emission tomography (PET) functional imaging is based on changes in regional cerebral blood flow (rCBF). Functional magnetic resonance imaging (fMRI) is based on a variety of physiological parameters as well as rCBF. This study is aimed at the cross validation of three-dimensional (3D) fMRI, which is sensitive to changes in blood oxygenation, with oxygen-15-labeled water ((H2O)-O-15) PET. Nine normal subjects repeatedly performed a simple finger opposition task during fMRI scans and during PET scans. Within-subject statistical analysis revealed significant (''activated'') signal changes (p < 0.05, Bonferroni corrected for number of voxels) in contralateral primary sensorimotor- cortex (PSM) in all subjects with fMRI and with PET. With both methods, 78% of all activated voxels were located in the PSM. Overlap of activated regions occurred in all subjects (mean 43%, SD 26%). The size of the activated regions in PSM with both methods was highly correlated (rho = 0.87, p < 0.01). The mean distance between centers of mass of the activated regions in the PSM for fMRI versus PET was 6.7 mm (SD 3.0 mm). Average magnitude of signal change in activated voxels in this region, expressed as z-values adapted to timeseries, z(t), was similar (fMRI 5.5, PET 5.3). Results indicate that positive blood oxygen level-dependent (BOLD) signal changes obtained with 3D principles of echo shifting with a train of observations (PRESTO) fMRI are correlated with rCBF, and that sensitivity of fMRI can equal that of (H2SO)-S-15 PET.