Spatial and Temporal Control of Evolution through Replication-Transcription Conflicts.
Spatial and Temporal Control of Evolution through Replication-Transcription Conflicts.
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DOI：
10.1016/j.tim.2017.01.008
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发表时间：
2017-07
影响因子：
15.9
通讯作者：
Merrikh H
中科院分区：
文献类型：
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作者：
Merrikh H
如果一个生物体能够选择性地增加处于积极选择下的特定基因的突变率，那么进化可能会加速。最近，发现了一种细胞可以用来将快速进化靶向特定基因的机制。这种机制是由DNA复制和转录机制之间的基因取向依赖性相遇驱动的。这些遭遇增加了滞后链基因的诱变，其中复制-转录冲突是严重的。由于该过程的方向和转录依赖性，冲突驱动的诱变可以被细胞用于空间（基因特异性）和时间（仅在转录诱导时）调节基因进化的速率。在这里，我总结了最近的研究结果在这个话题上，并讨论了增加诱变率和加速进化的积极机制的影响。
Evolution could potentially be accelerated if an organism could selectively increase the mutation rate of specific genes that are actively under positive selection. Recently, a mechanism that cells can use to target rapid evolution to specific genes was discovered. This mechanism is driven by gene orientation-dependent encounters between DNA replication and transcription machineries. These encounters increase mutagenesis in lagging strand genes, where replication-transcription conflicts are severe. Due to the orientation and transcription-dependent nature of this process, conflict-driven mutagenesis can be used by cells to spatially (gene-specifically) and temporally (only upon transcription induction) regulate the rate of gene evolution. Here, I summarize recent findings on this topic, and discuss the implications of increasing mutagenesis rates and accelerating evolution through active mechanisms.