Long-term exercise at different intensities can reduce the inflammatory response in the brains of methamphetamine-treated mice.
Long-term exercise at different intensities can reduce the inflammatory response in the brains of methamphetamine-treated mice.
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DOI：
10.2139/ssrn.4092359
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发表时间：
2022-05
影响因子：
3.1
通讯作者：
Yue Li;Guo-fen Re;Yu Zhao;Xiaocong Wu;Ruiyi Zhou;Yi‐Qun Kuang;Kun-hua Wang
中科院分区：
文献类型：
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作者：
Yue Li;Guo-fen Re;Yu Zhao;Xiaocong Wu;Ruiyi Zhou;Yi‐Qun Kuang;Kun-hua Wang
甲基苯丙胺（METH）是一种高度成瘾的精神药物，在世界各地使用。已经使用了各种方法来解决甲基苯丙胺的依赖性，但其中许多方法几乎没有效果。先前的研究表明，在跑步机上运动可以减少小鼠对METH的依赖，但有效的运动强度和持续时间尚不清楚。本研究通过条件性位置偏爱（CPP）训练，观察了中低强度跑台运动对雄性小鼠甲基苯丙胺奖赏的影响，并测定了小鼠大脑皮质、海马和纹状体3个脑区炎症因子IL-1β、IL-6和TNF-α的水平。结果表明，长期中等强度的运动减少了甲基苯丙胺对大脑炎症标志物和CPP评分的影响。此外，长期中等强度运动降低了甲基苯丙胺治疗小鼠大脑皮层和海马中的IL-1β浓度，降低了纹状体中的IL-6浓度，降低了大脑皮层、海马和纹状体中的TNF-α浓度;低强度运动效果较差。结果表明，长期中等强度运动可降低甲基苯丙胺诱导的雄性小鼠脑炎因子的浓度，而低强度运动对缓解依赖和炎症反应的效果较差。提示运动强度是影响甲基苯丙胺致小鼠脑内依赖水平和炎症反应的重要因素。
Methamphetamine (METH) is a highly addictive psychoactive drug that is used worldwide. Various approaches have been used to address METH dependence, but many of them have little effect. Previous studies have shown that exercise on a treadmill could reduce METH dependence in mice, but the intensity and duration of exercise that was needed to be effective was unknown. This study investigated the effects of low- and medium-intensity treadmill exercise on methamphetamine reward in male mice via conditioned place preference (CPP) training, and the levels of the inflammatory factors IL-1β, IL-6 and TNF-α in three brain regions (cerebral cortex, hippocampus and striatum) were determined. The results showed that long-term medium-intensity exercise reduced the effects of methamphetamine on inflammation markers in the brain and CPP scores. In addition, long-term medium-intensity exercise decreased IL-1β concentrations in the cerebral cortex and hippocampus, reduced IL-6 concentrations in the striatum, and reduced TNF-α concentrations in the cerebral cortex, hippocampus, and striatum in methamphetamine-treated mice; low-intensity exercise was less effective. The results indicated that long-term medium-intensity exercise could reduce concentrations of methamphetamine-induced encephalitis factors in male mice, while low-intensity exercise was less effective in alleviating dependence and inflammatory responses. It is suggested that exercise intensity is an important factor affecting the dependence level and inflammatory responses in the brain in mice administered methamphetamine.