Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance
Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance
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DOI：
10.1590/s1516-44462011005000009
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发表时间：
2011-09-01
影响因子：
5.5
通讯作者：
Gama, Clarissa Severino
中科院分区：
文献类型：
--
作者：
Kunz, Mauricio;Ceresér, Keila Maria;Gama, Clarissa Severino
目的：先前的报告表明，细胞因子是免疫系统和神经内分泌系统之间相互作用的潜在介质，促炎症状态可能与双相情感障碍和精神分裂症有关。目的是比较两种疾病的细胞因子水平。方法：招募了 20 名情绪正常的双相情感障碍患者、53 名慢性稳定型精神分裂症患者和 80 名健康对照者。受试者均不吸烟且不肥胖。通过夹心 ELISA 检查细胞因子 TNF-α、IL-6 和 IL-10。结果：与对照组 (p < 0.0001) 和正常双相情感障碍患者 (p < 0.0001) 相比，精神分裂症患者的 IL-6 水平升高。与心境正常的双相情感障碍患者相比，对照组的 IL-6 水平没有差异 (p = 0.357)。与精神分裂症患者 (p = 0.001) 或双相情感障碍患者 (p = 0.004) 相比，对照组的 IL-10 较低。各组间 TNF-α 血清水平无显着差异 (p = 0.284)。基于性别的分类并没有显着改变这些发现，并且没有发现精神分裂症患者的抗精神病药物剂量与细胞因子水平之间存在相关性。讨论：这些发现证明精神分裂症存在慢性免疫激活。双相情感障碍似乎呈现出与发作相关的炎症综合征。双相情感障碍和精神分裂症中抗炎因子 IL-10 的增加表明这两种疾病之间的炎症平衡模式不同。结果进一步支持研究细胞因子作为疾病活动或治疗反应的可能生物标志物的必要性。
Objective: Previous reports suggest that cytokines act as potential mediators of the interaction between the immune and neuroendocrine systems, and that a proinflammatory state may be associated with bipolar disorder and schizophrenia. The aim is to compare cytokine levels in both disorders. Method: Twenty euthymic bipolar disorder patients, 53 chronic stabilized schizophrenia patients and 80 healthy controls were recruited. Subjects were all non-smokers and non-obese. Cytokines TNF-alpha, IL-6, and IL-10 were examined by sandwich ELISA. Results: IL-6 levels were increased in schizophrenia patients when compared to controls (p < 0.0001) and euthymic bipolar disorder patients (p < 0.0001). IL-6 levels were no different in controls compared to euthymic bipolar disorder patients (p = 0.357). IL-10 was lower in controls compared to schizophrenia patients (p = 0.001) or to bipolar disorder patients (p = 0.004). There was no significant difference in TNF-alpha serum levels among the groups (p = 0.284). Gender-based classification did not significantly alter these findings, and no correlation was found between the antipsychotic dose administered and cytokine levels in patients with schizophrenia. Discussion: These findings evidence a chronic immune activation in schizophrenia. Bipolar disorder seems to present an episode-related inflammatory syndrome. Increased anti-inflammatory factor IL-10 in bipolar disorder and schizophrenia suggests different patterns of inflammatory balance between these two disorders. Results further support the need to investigate cytokines as possible biomarkers of disease activity or treatment response.