Artificial intelligence in COVID-19 drug repurposing.
Artificial intelligence in COVID-19 drug repurposing.
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DOI：
10.1016/s2589-7500(20)30192-8
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Cheng F
中科院分区：
文献类型：
--
作者：
Zhou Y;Wang F;Tang J;Nussinov R;Cheng F
药物重新利用或重新定位是一种技术，现有药物用于治疗新出现和挑战性疾病，包括COVID-19。由于有机会减少开发时间表和整体成本，因此药物重新利用已成为一种有前途的方法。在大数据时代，人工智能（AI）和网络医学为定义疾病，医学，治疗学和确定错误最小的靶标提供了信息科学的最新应用。在这篇综述中，我们介绍了有关如何使用AI加速药物重新利用或重新定位的指南，为此，AI方法不仅是可强大的，而且是必要的。我们讨论了如何在精确医学中使用AI模型，例如，AI模型如何加速Covid-19的药物重新利用。快速发展，强大和创新的AI和网络医学技术可以加快治疗发展。这篇综述为使用基于AI的辅助工具来重新利用人类疾病的药物（包括Covid-19期间大流行期间）提供了有力的理由。
Drug repurposing or repositioning is a technique whereby existing drugs are used to treat emerging and challenging diseases, including COVID-19. Drug repurposing has become a promising approach because of the opportunity for reduced development timelines and overall costs. In the big data era, artificial intelligence (AI) and network medicine offer cutting-edge application of information science to defining disease, medicine, therapeutics, and identifying targets with the least error. In this Review, we introduce guidelines on how to use AI for accelerating drug repurposing or repositioning, for which AI approaches are not just formidable but are also necessary. We discuss how to use AI models in precision medicine, and as an example, how AI models can accelerate COVID-19 drug repurposing. Rapidly developing, powerful, and innovative AI and network medicine technologies can expedite therapeutic development. This Review provides a strong rationale for using AI-based assistive tools for drug repurposing medications for human disease, including during the COVID-19 pandemic.