How electromagnetic fields can influence adult stem cells: positive and negative impacts.
How electromagnetic fields can influence adult stem cells: positive and negative impacts.
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DOI：
10.1186/s13287-016-0312-5
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发表时间：
2016-04-18
影响因子：
7.5
通讯作者：
Banas A
中科院分区：
文献类型：
--
作者：
Maziarz A;Kocan B;Bester M;Budzik S;Cholewa M;Ochiya T;Banas A
电磁场（EMF）对我们的身体有很大的影响。它已成功地用于物理治疗，用于治疗骨疾病和骨关节炎，以及用于软骨再生或减轻疼痛。最近，电磁场也被应用于细胞/干细胞培养物的体外实验中。干细胞存在于人体内的几乎所有组织中，在那里它们表现出各种潜力。这些细胞非常重要，因为它们控制体内平衡，再生和愈合。然而，干细胞当成为癌症干细胞时，可能会影响病理状态。在这篇文章中，我们回顾了目前的知识，电磁场对人类成体干细胞生物学的影响，如增殖，细胞周期，或分化。我们提出了在杂项测定中使用的电磁场的特性。迄今为止，大多数研究都是在间充质干细胞的成骨和成软骨分化过程中进行的。研究表明，电磁场刺激的效应取决于电磁场的强度和频率以及暴露于电磁场的时间。然而，其他因素也可能影响这些过程，如生长因子、活性氧等。对这一研究领域的探索可能会促进基于电磁场的技术在医学应用中的发展，从而改善基于干细胞的治疗和组织工程。
The electromagnetic field (EMF) has a great impact on our body. It has been successfully used in physiotherapy for the treatment of bone disorders and osteoarthritis, as well as for cartilage regeneration or pain reduction. Recently, EMFs have also been applied in in vitro experiments on cell/stem cell cultures. Stem cells reside in almost all tissues within the human body, where they exhibit various potential. These cells are of great importance because they control homeostasis, regeneration, and healing. Nevertheless, stem cells when become cancer stem cells, may influence the pathological condition. In this article we review the current knowledge on the effects of EMFs on human adult stem cell biology, such as proliferation, the cell cycle, or differentiation. We present the characteristics of the EMFs used in miscellaneous assays. Most research has so far been performed during osteogenic and chondrogenic differentiation of mesenchymal stem cells. It has been demonstrated that the effects of EMF stimulation depend on the intensity and frequency of the EMF and the time of exposure to it. However, other factors may affect these processes, such as growth factors, reactive oxygen species, and so forth. Exploration of this research area may enhance the development of EMF-based technologies used in medical applications and thereby improve stem cell-based therapy and tissue engineering.