Unique Sensitivity of Uterine Tissue and the Immune System for Endometriotic Lesion Formation.
Unique Sensitivity of Uterine Tissue and the Immune System for Endometriotic Lesion Formation.
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DOI：
10.3389/fphys.2021.805784
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发表时间：
2021
影响因子：
4
通讯作者：
Burns KA
中科院分区：
文献类型：
--
作者：
Morris SA;Korach KS;Burns KA
子宫内膜异位症是一种使人衰弱的疾病，大约10%的育龄青少年和妇女会受到影响。该病的病因尚不清楚，然而，一种流行的假说是，子宫内膜异位症发生于月经逆行，即子宫内膜组织和液体通过输卵管回流到腹膜腔。子宫内膜异位症无法治愈，症状只能姑息治疗。尽管人们对子宫内膜异位症的认识有了很大的进步，但其病因的复杂性仍不清楚。我们小组最近的工作表明，子宫内膜异位症的发生是免疫依赖性的。利用小鼠子宫内膜异位症模型，我们假设子宫内膜异位症的起始是免疫调节的，并且是子宫内膜特异性的。在缺乏功能性免疫系统非肥胖糖尿病/严重联合免疫缺陷(NOD/SCID小鼠)的情况下，子宫内膜异位症病变没有形成。子宫内膜组织形成异位内膜病变，而雌激素受体α(ESR1)和雌激素受体β(ESR2)基础表达水平不同、细胞成分与子宫相似的组织(即膀胱、乳腺和肺)，经雌激素处理后不形成病变。由于MMP7在月经周期中子宫内膜的组织/重组中起主要作用，阻断金属蛋白酶(MMP7)活性可显著降低这些细胞的侵袭性。综上所述，这些发现表明子宫内膜异位症具有免疫性和子宫特异性，MMP7可能在子宫组织和先天免疫系统建立和维持子宫内膜异位症病变的能力中发挥作用。
Endometriosis is a debilitating disease that affects about 10% of reproductive-aged adolescents and women. The etiology of the disease is unknown; however, a prevailing hypothesis is that endometriosis develops from retrograde menstruation, where endometrial tissue and fluids flow back through the oviducts into the peritoneal cavity. There is no cure for endometriosis, and symptoms are treated palliatively. Despite the advances in knowledge, the complexity of endometriosis etiology is still unknown. Recent work by our group suggests that the initiation of endometriosis is immune-dependent. Using a mouse model of endometriosis, we hypothesized the initiation of endometriosis is immune regulated and uterine endometrium specific. In the absence of a functional immune system non-obese diabetic/severe combined immunodeficiency (NOD/SCID mice), endometriotic lesions did not form. Uterine endometrial tissue forms endometriotic lesions, whereas tissues with differing basal expression levels of estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), similar cellular composition to uterus (i.e. bladder, mammary gland, and lung), and treated with estradiol did not form lesions. As MMP7 is known to play a major role in the organization/reorganization of the endometrium during the menstrual cycle, blocking metalloproteinase (MMP) activity significantly decreased the invasive properties of these cells. Together, these findings suggest that endometriosis is immune and uterine specific and that MMP7 likely plays a role in the ability of uterine tissue and the innate immune system to establish and maintain endometriotic lesions.
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影响因子：
20.3
作者：
Christoffersson, Gustaf;Vagesjo, Evelina;Phillipson, Mia
通讯作者：
Phillipson, Mia
影响因子：
3.4
作者：
Bałkowiec M;Maksym RB;Włodarski PK
通讯作者：
Włodarski PK
影响因子：
5.8
作者：
Bruner-Tran, KL;Zhang, ZM;Osteen, KG
通讯作者：
Osteen, KG
DOI：
10.1111/j.1749-6632.2002.tb02791.x
发表时间：
2002-01-01
期刊：
ENDOMETRIOSIS: EMERGING RESEARCH AND INTERVENTION STRATEGIES
影响因子：
--
作者：
Fazleabas, AT;Brudney, A;Bulun, S
通讯作者：
Bulun, S
影响因子：
20.3
作者：
Fantin, Alessandro;Vieira, Joaquim M.;Ruhrberg, Christiana
通讯作者：
Ruhrberg, Christiana