The global circulation of seasonal influenza A (H3N2) viruses
The global circulation of seasonal influenza A (H3N2) viruses
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DOI：
10.1126/science.1154137
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发表时间：
2008-04-18
期刊：
影响因子：
56.9
通讯作者：
Smith, Derek J.
中科院分区：
文献类型：
--
作者：
Russell, Colin A.;Jones, Terry C.;Smith, Derek J.
对2002- 2007年期间来自六大洲的13，000株人类甲型流感（H3 N2）病毒的血凝素进行的抗原和遗传分析显示，东亚和东南亚（E-SE Asia）通过时间重叠的流行病区域网络持续传播，温带地区的流行病每年都从该网络传播。种子株通常首先到达大洋洲，北美和欧洲，后来到达南美洲。这一证据表明，一旦A（H3 N2）病毒离开东南亚，它们就不太可能有助于病毒的长期进化。如果在此期间观察到的趋势能够准确地反映总体传播模式，那么每年就可以根据东南亚地区的监测情况预测东南亚地区以外的甲型H3 N2流感病毒的抗原特征，从而改进疫苗株的选择。
Antigenic and genetic analysis of the hemagglutinin of similar to 13,000 human influenza A ( H3N2) viruses from six continents during 2002- 2007 revealed that there was continuous circulation in east and Southeast Asia ( E- SE Asia) via a region- wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A ( H3N2) viruses leave E- SE Asia, they are unlikely to contribute to long- term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A ( H3N2) viruses outside E- SE Asia may be forecast each year based on surveillance within E- SE Asia, with consequent improvements to vaccine strain selection.