Increased cancellous bone remodeling during lactation in beagles.
Increased cancellous bone remodeling during lactation in beagles.
复制标题
比格犬哺乳期间松质骨重塑增加。
DOI：
10.1016/8756-3282(89)90065-3
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发表时间：
1989
期刊：
影响因子：
4.1
通讯作者：
Miller,SC
中科院分区：
文献类型：
--
作者：
Miller,MA;Omura,TH;Miller,SC
在成年比格犬哺乳期间测定骨量和松质骨重建参数的变化。骨矿物质含量通过光子吸收测定法测定，矿化松质骨面积分数和周长与面积比通过显微放射照片的图像分析测定，骨重建参数通过基于荧光染料的组织形态测定法测定。与对照组相比，哺乳期完整肱骨近端的骨矿物质含量和腰椎松质骨矿化组织区域的分数降低。哺乳期类骨质体积和类骨质表面显著增加，尽管类骨质接缝厚度没有变化。与对照组相比，哺乳期犬的荧光染料标记松质骨表面分数显著增加。与对照组相比，哺乳期犬的矿化表面、骨形成率和激活频率显著增加。泌乳期间吸收参数也显著增加。这些数据表明，在哺乳期，骨重建和骨转换增加。长寿哺乳动物在哺乳期间增加的骨重塑可能代表了“可逆性矿物质缺乏”的一个例子，这可能是哺乳母亲确保牛奶生产充足钙的重要生理机制。增加的骨重塑也可以提供一种生理机制，以增强骨骼的能力，以更好地适应哺乳期间矿物质稳态的大幅增加和偶发性变化。
Changes in bone mass and cancellous bone remodeling parameters were determined during lactation in adult beagles. Bone mineral content was determined by photon absorptiometry, fraction of mineralized cancellous bone area and perimeter to area ratios by image analysis of microradiographs, and bone remodeling parameters by fluorochrome-based histomorphometry. Bone mineral content of the intact proximal humerus and fraction of mineralized tissue areas of lumbar vertebral cancellous bone were decreased during lactation when compared with controls. There were significant increases during lactation in osteoid volumes and osteoid surface, although osteoid seam thickness was not changed. There were significant increases in the fraction of fluorochrome-labeled cancellous bone surfaces in the lactating dogs when compared with controls. The mineralizing surface, bone formation rate and activation frequency were significantly increased in the lactating dogs when compared with controls. There were also significant increases in resorption parameters during lactation. These data indicate that during lactation, bone remodeling and bone turnover is increased. Increased bone remodeling during lactation in a longer-lived mammal may represent an example of a “reversible mineral deficit” which may be an important physiological mechanism in nursing mothers to ensure adequate calcium for milk production. Increased bone remodeling may also provide a physiological mechanism to enhance the capacity of the skeleton to better accommodate the greatly increased and episodic changes in mineral homeostasis during lactation.