Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis
Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis
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DOI：
10.1111/j.1600-051x.2011.01764.x
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发表时间：
2011-10-01
影响因子：
6.7
通讯作者：
Chapple, Iain L.
中科院分区：
文献类型：
--
作者：
Allen, Edith M.;Matthews, John B.;Chapple, Iain L.
目的：探讨牙周炎对2型糖尿病氧化/炎症状态和糖尿病控制的影响。材料与方法：对20例伴有牙周炎的2型糖尿病患者[体重指数（BMI） 31+5]、20例年龄/性别匹配的非牙周炎2型糖尿病对照组（BMI 29+6）和20例非糖尿病牙周炎对照组（BMI 25+4）进行牙周检查并采集空腹血液样本进行比较研究。用血浆小分子抗氧化能力（pSMAC）和蛋白羰基水平测定氧化应激；总/差异白细胞、纤维蛋白原和高敏c反应蛋白（hsCRP）的炎症状态；通过空腹血糖、糖化血红蛋白、血脂、胰岛素抵抗和分泌来判断糖尿病状态。采用SPSS进行统计分析。结果：伴有牙周炎的2型糖尿病患者pSMAC低于无牙周炎患者（p=0.03），蛋白羰基高于无牙周炎患者（p=0.007）。糖尿病患者牙周炎与较高的HbA1c （p=0.002）和空腹血糖水平（p=0.04）以及较低的β细胞功能（homa - β, p=0.01）相关。牙周炎对炎症标志物或脂质谱的影响很小，但患有牙周炎的2型糖尿病患者的hsCRP水平高于无糖尿病患者（p=0.004）， hdl -胆固醇水平在所有组中最低。结论：牙周炎与2型糖尿病患者氧化应激增加和血糖控制受损有关。
Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower beta-cell function (HOMA-beta; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.