INTRON PHYLOGENY - A NEW HYPOTHESIS
INTRON PHYLOGENY - A NEW HYPOTHESIS
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DOI：
10.1016/0168-9525(91)90102-v
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发表时间：
1991-05-01
影响因子：
11.4
通讯作者：
CAVALIERSMITH, T
中科院分区：
文献类型：
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作者：
CAVALIERSMITH, T
这三种主要的内含子的古老程度显然是不一样的。 结构化（通常自我剪接，有时移动的）内含子是最古老的，可能（至少对于第I组）来自35亿年前的祖先（真细菌）细胞，最初仅限于tRNA。 蛋白质剪接的内含子（通常在tRNA中）可能是由真核生物和古细菌共同祖先的剪接机制发生根本性变化而进化而来的，也许只有大约17亿年前。 剪接体内含子可能是在17亿至10亿年前细胞核形成后，从II类自我剪接内含子进化而来，并且可能在10亿年前线粒体形成后，大部分插入到先前未分裂的蛋白质编码基因中。
The three major classes of intron are clearly of unequal antiquity. Structured (often self-splicing and sometimes mobile) introns are the most ancient, probably dating (at least for group I) from the ancestral (eubacterial) cell 3500 million years ago, and were originally restricted to tRNA. Protein-spliced introns (usually in tRNA) probably evolved from them by a radical change in splicing mechanism in the common ancester of eukaryotes and archaebacteria, perhaps only about 1700 million years ago. Spliceosomal introns probably evolved from group-II-like self-splicing introns after the origin of the nucleus between 1700 and 1000 million years ago, and were probably mostly inserted into previously unsplit protein-coding genes after the origin of mitochondria 1000 million years ago.