BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES
BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES
复制标题
DOI：
10.1126/science.8128245
复制
发表时间：
1994-03-18
期刊：
影响因子：
56.9
通讯作者：
LANGER, R
中科院分区：
文献类型：
--
作者：
GREF, R;MINAMITAKE, Y;LANGER, R
可注射的纳米颗粒载体具有重要的潜在应用，例如位点特异性药物递送或医学成像。然而，常规载体通常不能使用，因为它们在静脉内注射后数秒或数分钟内被网状内皮系统消除。为了解决这些局限性，单分散生物可降解纳米球是从两个生物相容性嵌段组成的两亲性共聚物开发的。纳米球在小鼠中表现出显著增加的血液循环时间和减少的肝脏积累。此外，它们在一步程序中将高达45%重量的药物包埋在致密的核心中，并且可以冷冻干燥，并且在水溶液中容易再分散，而无需添加剂。
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these limitations, monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks. The nanospheres exhibited dramatically increased blood circulation times and reduced liver accumulation in mice. Furthermore, they entrapped up to 45 percent by weight of the drug in the dense core in a one-step procedure and could be freeze-dried and easily redispersed without additives in aqueous solutions.