MHC class I and class II genes in Mexican patients with Chagas disease
MHC class I and class II genes in Mexican patients with Chagas disease
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DOI：
10.1016/j.humimm.2003.10.008
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发表时间：
2004-01-01
期刊：
影响因子：
2.7
通讯作者：
Vargas-Alarcón, G
中科院分区：
文献类型：
--
作者：
Cruz-Robles, D;Reyes, PA;Vargas-Alarcón, G
恰加斯病是几个拉丁美洲国家心血管疾病发病率和死亡率的重要原因。以往的研究报道了人类白细胞抗原（HLA）分子在克氏锥虫感染的免疫应答调节中的作用，以及HLA抗原与心脏损害的关系。我们研究了主要组织相容性复合体（MHC）I类（HLA-A和HLA-B），和II类（HLA-DR）基因在66个血清学阳性的个人和没有心肌病的样本，并在127名健康对照。与健康对照组相比，血清学阳性个体的总组显示HLA-B39（p（c）= 4.3 × 10（-5），比值比[OR] = 3.35）和DR 4（p（c）= 1.8 × 10（-5），OR = 2.91）的频率增加。与心肌病患者相比，在无症状个体中发现HLA-A68和HLA-B39的频率增加（分别为p（c）= 0.014，OR = 4.99和p（c）= 0.001，OR = 4.46）。此外，与健康对照组相比，心肌病患者表现出HLA-B35频率增加（p（c）= 0.048，OR = 2.56）。与无症状个体（p（c）= 0.05，OR =未确定）和健康对照（p（c）= 0.02，OR = 5.0）相比，心肌病患者的HLA-DR 16频率增加。结果表明，MHC等位基因可能与慢性感染的发展和心脏损害的恰加斯病。HLA-DR 4和HLA-B39与T.而HLA-DR 16可能是心肌损伤易感性的标志，HLA-A68可能对心肌病的发生具有保护作用。
Chagas' disease contributes significantly to cardiovascular morbidity and mortality in several Latin-American countries. Previous studies have reported the effect of the human leukocyte antigen (HLA) molecules in the immune response regulation of Trypanosoma cruzi infection, and the association of HLA antigens with heart damage. We studied the major histocompatibility complex (MHC) class I (HLA-A and HLA-B), and class II (HLA-DR) genes in a sample of 66 serologically positive individuals with and without cardiomyopathy, and in 127 healthy controls. The total group of seropositive individuals revealed increased frequencies of HLA-B39 (p(c) = 4.3X10(-5), odds ratio [OR] = 3.35) and DR4 (p(c) = 1.8X10(-5), OR = 2.91) when compared to healthy controls. Increased frequencies of HLA-A68 and HLA-B39 were found in asymptomatic individuals when compared to patients with cardiomyopathy (p(c) = 0.014, OR = 4.99 and p(c) = 0.001, OR = 4.46, respectively). Also, patients with cardiomyopathy exhibited increased frequency of HLA-B35 when compared to healthy controls (p(c) = 0.048, OR = 2.56). The HLA-DR16 frequency was increased in patients with cardiomyopathy compared with asymptomatic individuals (p(c) = 0.05, OR = No determined) and healthy controls (p(c) = 0.02, OR = 5.0). The results suggest that MHC alleles might be associated with the development of chronic infection and with heart damage in Chagas' disease. HLA-DR4 and HLA-B39 could be associated directly with the infection by T. cruzi, whereas, HLA-DR16 could be marker of susceptibility to heart damage and HLA-A68 might confer protection to develop cardiomyopathy.