New azaphilones from the inedible mushroom Hypoxylon rubiginosum
New azaphilones from the inedible mushroom Hypoxylon rubiginosum
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DOI：
10.1021/np040063l
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Asakawa, Y
中科院分区：
文献类型：
--
作者：
Quang, DN;Hashimoto, T;Asakawa, Y
从木霉子实体的甲醇提取物中分离得到3个新的氮杂环酮类化合物，命名为Rubiginosins A-C(13)和一个新的脂肪酸，命名为Rubiginsic acid(4)，以及3个已知的化合物，entonaminin A(5)，daldinin C(6)，orsellinic acid。其结构经2D核磁共振、MS、IR、UV光谱和化学反应确证。通过圆二色谱确定了化合物3的绝对构型。4的结构经X-射线单晶分析确证。
Fractionation of the methanol extract of the fruit bodies of the xylariaceus ascomycete Hypoxylon rubiginosum resulted in the isolation of three new azaphilone derivatives named rubiginosins A-C (13) and a new fatty acid named rubiginosic acid (4), together with three known compounds, entonaemin A (5), daldinin C (6), and orsellinic acid. Their structures were elucidated by 2D NMR, MS, IR, and UV spectra and chemical reaction. The absolute configuration of compound 3 was established by CD spectroscopy. The structure of 4 was confirmed by X-ray crystallographic analysis.