Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat
Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat
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DOI：
10.1016/s0006-8993(97)00810-x
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发表时间：
1997-10-24
期刊：
影响因子：
2.9
通讯作者：
McGregor, IS
中科院分区：
文献类型：
--
作者：
Jinks, AL;McGregor, IS
一系列实验检测了大鼠的行为和自主神经方面的压力和焦虑，这些大鼠经历了以下任一种情况：（1）内侧前额叶皮层的边缘下皮层亚区的电解损伤;（2）内侧前额叶皮层的边缘前皮层亚区的电解损伤;（3）边缘下皮层或边缘前皮层的假损伤（假对照）;或（4）无损伤（对照）。在基于探索的焦虑模型中，infarimbic-or prelimbic-lesioned大鼠在开放场地的中心花费的时间更少，在高架十字迷宫暴露的手臂上花费的时间更少，表明焦虑增加。在非应激封闭环境中测试时，受损大鼠的运动活动正常。在降压被动回避任务中，边缘损伤的大鼠比对照组更快地走到24小时前受到电击的网格地板上。在这个测试中，尽管在条件反射过程中它们表现出更大的自由度，但在这个测试中，受到神经损伤的大鼠与对照组没有什么不同。在最后一个实验中，间接量热法被用来表明，infarimbic和prelimbic损伤大鼠有基本正常的变化，在氧气消耗和能量底物利用时，暴露于短暂的电击。因此，受损的被动回避infraalimbic-lesioned大鼠不能归因于减少伤害性感受。它的结论是，前边缘和边缘下区在焦虑中发挥作用，这种作用可能是微妙的区别。特别是，边缘下皮层可能在介导与厌恶结果相关的行为抑制中发挥特定作用。(C)1997年Elsevier Science B.V.
A series of experiments examined behavioural and autonomic aspects of stress and anxiety in rats subjected to either: (1) electrolytic lesions of the infralimbic cortex subregion of the medial prefrontal cortex; (2) electrolytic lesions of the prelimbic cortex subregion of the medial prefrontal cortex; (3) sham lesions of infralimbic or prelimbic cortex (sham control); or (4) no lesions (control). In exploration-based models of anxiety, infralimbic-or prelimbic-lesioned rats spent less time in the centre of an open field and less time on the exposed arms of an elevated plus maze, indicating increased anxiety. Locomotor activity was normal in the lesioned rats when tested in a non-stressful enclosed environment. In a step-down passive avoidance task, infralimbic-lesioned rats stepped down more quickly than controls onto a grid floor where they had been shocked 24 h previously. Prelimbic-lesioned rats were no different to controls on this test, although they showed greater latencies to step down onto the grid floor during conditioning. In a final experiment, indirect calorimetry was used to show that both infralimbic-and prelimbic-lesioned rats have essentially normal alterations in oxygen consumption and energy substrate utilisation when exposed to brief footshock. Thus, the impaired passive avoidance in infralimbic-lesioned rats cannot be attributed to decreased nociception. It is concluded that both the prelimbic and infralimbic regions play a role in anxiety, and that this role may be subtly differentiated. In particular, the infralimbic cortex may have a specific role in mediating the inhibition of behaviours associated with aversive outcomes. (C) 1997 Elsevier Science B.V.