Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan
Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan
复制标题
DOI：
10.3945/ajcn.111.020479
复制
发表时间：
2012-01-01
影响因子：
7.1
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Hara, Azusa;Sasazuki, Shizuka;Tsugane, Shoichiro
背景：异黄酮在结构上与17 β -雌二醇相似，可能具有预防胃癌的作用。然而，关于摄入富含异黄酮的大豆食品与胃癌之间的关系，目前存在相互矛盾的证据。与胃癌的关系可能在异黄酮和大豆食品之间有所不同，因此需要研究单独摄入异黄酮对胃癌的影响。目的：探讨异黄酮摄入与胃癌发病的关系。设计：我们对年龄在45-74岁之间的39,569名男性和45,312名女性进行了一项大规模的、基于人群的前瞻性研究。1995年和1998年，我们使用一份经过验证的食物频率问卷来测量膳食中大豆和异黄酮的摄入量。结果：在806,550人年的随访中，我们发现了1249例新发胃癌病例。无论男性还是女性，摄入异黄酮都与胃癌无关。与最低四分位数相比，摄入异黄酮的第四个四分位数中男性发生胃癌的HR和95% CI分别为1.00（0.81,1.24）和1.07（0.77,1.50）。然而，在外源性女性激素（仅限女性）的分层分析中，我们发现外源性女性激素使用者的胃癌风险增加趋势与异黄酮摄入量增加相关（P-trend = 0.03），而非外源性女性激素使用者的胃癌风险增加趋势与异黄酮摄入量增加相关（P-interaction = 0.04）。结论：目前的研究不支持高异黄酮摄入量可以预防男性或女性胃癌的假设。[J]中华临床医学杂志，2012;25(5):397 - 397。
Background: Isoflavones are structurally similar to 17 beta-estradiol and may be able to prevent gastric cancer. However, there is contradictory evidence concerning the relation between the intake of soy food, which is rich in isoflavones, and gastric cancer. The association with gastric cancer might differ between isoflavones and soy foods, and research on the effects of isoflavone intake alone on gastric cancer is needed.Objective: We investigated the association between isoflavone intake and the incidence of gastric cancer.Design: We conducted a large, population-based prospective study of 39,569 men and 45,312 women aged 45-74 y. Dietary soy and isoflavone intakes were measured by using a validated food-frequency questionnaire in 1995 and 1998.Results: During 806,550 person-years of follow-up, we identified 1249 new gastric cancer cases. Isoflavone intake was not associated with gastric cancer in either men or women. Compared with the lowest quartile, the HR and 95% CI for developing gastric cancer in the fourth quartile of isoflavone intake was 1.00 (0.81, 1.24) for men and 1.07 (0.77, 1.50) for women. In a stratified analysis by exogenous female hormones (women only), however, we found an increasing trend in risk of gastric cancer associated with higher isoflavone intakes among exogenous female hormone users (P-trend = 0.03) but not for nonusers (P-interaction = 0.04).Conclusion: The current study does not support the hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women. Am J Clin Nutr 2012;95:147-54.