Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa.
Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa.
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DOI：
10.1016/j.psychres.2015.05.040
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发表时间：
2015-08-30
影响因子：
11.3
通讯作者：
McAdams CJ
中科院分区：
文献类型：
--
作者：
Acevedo SF;Valencia C;Lutter M;McAdams CJ
催产素是一种对社会行为很重要的肽类激素，健康人的心理特征差异与催产素受体基因的变异有关。我们研究了催产素受体基因（OXTR）的小核苷酸多态性（SNP）是否与神经性厌食症、神经性贪食症和健康对照（HC）女性的临床症状相关。受试者完成临床评估并提供DNA用于分析。受试者被分为四组：HC、目前患有神经性厌食症的受试者（AN-C）、有神经性厌食症病史但体重长期恢复的受试者（AN-WR）和患有神经性贪食症的受试者（BN）。研究了催产素受体的五个SNP。少数等位基因携带者在大多数精神病症状中表现出更严重的程度。重要的是，患有厌食症并携带OXTR基因中两个SNPS的A等位基因（rs 53576，rs 2254298）中的任一个的组合与艾德症状的严重程度增加相关，包括与进食和外观相关的认知和行为。审查相关的OXTR多态性检查的心理社会数据包括在讨论中。OXTR多态性可能是一个有用的中间内表型，考虑在神经性厌食症患者的治疗。
Oxytocin is a peptide hormone important for social behavior, and differences in psychological traits have been associated with variants of the oxytocin receptor gene in healthy people. We examined whether small nucleotide polymorphisms (SNPs) of the oxytocin receptor gene (OXTR) correlated with clinical symptoms in women with anorexia nervosa, bulimia nervosa, and healthy comparison (HC) women. Subjects completed clinical assessments and provided DNA for analysis. Subjects were divided into four groups: HC, subjects currently with anorexia nervosa (AN-C), subjects with a history of anorexia nervosa but in long-term weight recovery (AN-WR), and subjects with bulimia nervosa (BN). Five SNPs of the oxytocin receptor were examined. Minor allele carriers showed greater severity in most of the psychiatric symptoms. Importantly, the combination of having had anorexia and carrying either of the A alleles for two SNPS in the OXTR gene (rs53576, rs2254298) was associated with increased severity specifically for ED symptoms including cognitions and behaviors associated both with eating and appearance. A review of psychosocial data related to the OXTR polymorphisms examined is included in the discussion. OXTR polymorphisms may be a useful intermediate endophenotype to consider in the treatment of patients with anorexia nervosa.