UTEROGLOBIN INHIBITS PHOSPHOLIPASE-A2 ACTIVITY
UTEROGLOBIN INHIBITS PHOSPHOLIPASE-A2 ACTIVITY
复制标题
DOI：
10.1016/0024-3205(86)90135-9
复制
发表时间：
1986-05-19
期刊：
影响因子：
6.1
通讯作者：
MUKHERJEE, AB
中科院分区：
文献类型：
--
作者：
LEVIN, SW;BUTLER, JD;MUKHERJEE, AB
尽管已知黄体酮可以在哺乳动物子宫中产生静止，但这种效应的机制尚不清楚。在这里，我们报道了子宫珠蛋白，一种孕激素诱导的小分子量 (16K) 蛋白，可抑制源自猪胰腺以及 RAW 264.7 巨噬细胞系的磷脂酶 A2(PLA2)。我们推测黄体酮可能通过子宫珠蛋白对子宫发挥抗蠕动作用，子宫珠蛋白通过抑制 PLA2 减少花生四烯酸的释放，从而降低该器官中前列腺素的水平。这可以解释为什么黄体酮对于几乎所有哺乳动物的妊娠维持如此重要。
Although progesterone is known to produce quiescence in the mammlian uterus, the mechanism of this effect is not clearly understood. Here, we report the uteroglobin, a progesteron-induced small molecular weight (16K) protein, inhibits phospholipase A2(PLA2) derived from porcine pancreas as well as from the RAW 264.7 macrophage cell line. We speculate that progesterone may exert its antimotility effects on the uterus via uteroglobin which, by inhibiting PLA2, decreases arachidonic acid release and subsequently reduces prostaglandin levels in this organ. This may explain why progesterone is so vital for the maintenance of pregnancy in almost all mammals.