Effects of acute psychosocial stress on neural activity to emotional and neutral faces in a face recognition memory paradigm
Effects of acute psychosocial stress on neural activity to emotional and neutral faces in a face recognition memory paradigm
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DOI：
10.1007/s11682-013-9287-3
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发表时间：
2014-12-01
影响因子：
3.2
通讯作者：
Thiel, Christiane M.
中科院分区：
文献类型：
--
作者：
Li, Shijia;Weerda, Riklef;Thiel, Christiane M.
先前的研究表明，急性心理压力会损害陈述性记忆的识别，而情感材料对这种影响尤其敏感。动物研究表明，杏仁核在调节海马体、前额皮质和其他大脑区域的记忆过程中起着核心作用。我们使用功能磁共振成像（fMRI）来研究人类情绪识别记忆的应激诱导调制的神经相关性。27名健康、右撇子、不吸烟的男性志愿者进行了一项情绪化的人脸识别任务。在编码过程中，参与者看到了50张恐惧和50张中性的面孔。一小时后，他们在扫描仪外接受了压力（特里尔社会压力测试）或控制程序，随后立即进行扫描仪内的识别会话，参与者必须区分100张旧面孔和50张新面孔。压力增加了唾液皮质醇，血压和脉搏，降低了参与者的情绪，但不影响识别记忆。BOLD数据在识别过程中揭示了一个压力条件下的情绪互动，在左额下回和右海马，这是由于压力引起的神经活动的增加，恐惧和减少中性面孔。功能连接分析显示，与中性面孔相比，当处理恐惧时，右杏仁核和右梭状回之间的耦合会因压力而增加。我们的研究结果提供的证据表明，急性心理社会压力影响内侧颞叶和额叶脑区差异中性和情绪的项目，与压力引起的特权处理情绪刺激。
Previous studies have shown that acute psychosocial stress impairs recognition of declarative memory and that emotional material is especially sensitive to this effect. Animal studies suggest a central role of the amygdala which modulates memory processes in hippocampus, prefrontal cortex and other brain areas. We used functional magnetic resonance imaging (fMRI) to investigate neural correlates of stress-induced modulation of emotional recognition memory in humans. Twenty-seven healthy, right-handed, non-smoker male volunteers performed an emotional face recognition task. During encoding, participants were presented with 50 fearful and 50 neutral faces. One hour later, they underwent either a stress (Trier Social Stress Test) or a control procedure outside the scanner which was followed immediately by the recognition session inside the scanner, where participants had to discriminate between 100 old and 50 new faces. Stress increased salivary cortisol, blood pressure and pulse, and decreased the mood of participants but did not impact recognition memory. BOLD data during recognition revealed a stress condition by emotion interaction in the left inferior frontal gyrus and right hippocampus which was due to a stress-induced increase of neural activity to fearful and a decrease to neutral faces. Functional connectivity analyses revealed a stress-induced increase in coupling between the right amygdala and the right fusiform gyrus, when processing fearful as compared to neutral faces. Our results provide evidence that acute psychosocial stress affects medial temporal and frontal brain areas differentially for neutral and emotional items, with a stress-induced privileged processing of emotional stimuli.