The association between endometrial thickness and pregnancy outcome in gonadotropin-stimulated intrauterine insemination cycles
The association between endometrial thickness and pregnancy outcome in gonadotropin-stimulated intrauterine insemination cycles
复制标题
促性腺激素宫腔内人工授精周期子宫内膜厚度与妊娠结局的关系
DOI：
10.1186/s12958-019-0455-1
复制
发表时间：
2019-01-23
影响因子：
4.4
通讯作者：
Chan, Crystal
中科院分区：
文献类型：
--
作者：
Liu, Yiwen;Ye, Xiang Y.;Chan, Crystal
背景子宫内人工授精（IUI）是治疗非输卵管性不孕症的一线方法。在IUI周期中，注射促性腺激素常被选择作为促排卵刺激，以促进卵泡生长。生长中的卵泡产生雌激素，雌激素诱导子宫内膜增殖和子宫内膜条纹厚度（EST）增加。在促性腺激素刺激的IUI中，EST与妊娠结局之间的关系尚未得到充分研究。本研究的目的是确定EST是否可以预测妊娠结局在促性腺激素刺激的IUI cycles.MethodsA回顾性审查进行了2012年和2015年之间进行的所有专门促性腺激素刺激的IUI周期在学术生育诊所。采用Student T检验比较阳性与阴性周期的平均子宫内膜厚度。然后将EST峰值分为四组，
BackgroundIntrauterine insemination (IUI) is the first-line treatment for non-tubal infertility. Injectable gonadotropins are often chosen as adjunctive stimulation to promote the growth of ovarian follicles in IUI cycles. The growing follicles produce estrogen, which induces endometrial proliferation and increased endometrial stripe thickness (EST). The association between EST and pregnancy outcome in gonadotropin stimulated IUI is not well studied. The objective of this study is to determine if EST can predict pregnancy outcome in gonadotropin-stimulated IUI cycles.MethodsA retrospective review was conducted of all exclusively gonadotropin-stimulated IUI cycles performed between 2012 and 2015 at an academic fertility clinic. Mean endometrial thickness was compared in positive versus negative cycles using Student T-test. Peak EST values were then divided into four groups of