ORAL ALPHA-TOCOPHEROL SUPPLEMENTS DECREASE PLASMA GAMMA-TOCOPHEROL LEVELS IN HUMANS
ORAL ALPHA-TOCOPHEROL SUPPLEMENTS DECREASE PLASMA GAMMA-TOCOPHEROL LEVELS IN HUMANS
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DOI：
10.1093/jn/115.6.807
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发表时间：
1985-01-01
影响因子：
4.2
通讯作者：
DRATZ, EA
中科院分区：
文献类型：
--
作者：
HANDELMAN, GJ;MACHLIN, LJ;DRATZ, EA
In a cross-sectional survey of 86 elderly persons, it was observed that subjects with elevated plasma .alpha.-tocopherol levels had depressed plasma .gamma.-tocopherol. Tocopherols were measured by both reverse-phase and normal-phase high-performance liquid chromatography (HPLC). When 8 human volunteers (age range 30-60) were given 1200 IU of all-rac-.alpha.-tocopherol daily for 8 wk, plasma .gamma.-tocopherol and .beta.-tocopherol decreased in all subjects. After supplementation, .gamma.-tocopherol values were typically 30-50% of initial values, and .alpha.-tocopherol values were typically 200-400% of initial values. These results suggest that intestinal uptake and/or plasma transport make more efficient use of .alpha.-tocopherol than of .gamma.- or .beta.-tocopherol. Moreover, the results indicate that the ratio of .gamma.- to .alpha.-tocopherol in plasma would be a more satisfactory index to measure compliance in trials involving supplementation with .alpha.-tocopherol.
