Vibrissa sensation in superior colliculus: wide-field sensitivity and state-dependent cortical feedback.
Vibrissa sensation in superior colliculus: wide-field sensitivity and state-dependent cortical feedback.
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DOI：
10.1523/jneurosci.2999-08.2008
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发表时间：
2008-10-29
期刊：
影响因子：
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通讯作者：
Castro-Alamancos MA
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文献类型：
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作者：
Cohen JD;Hirata A;Castro-Alamancos MA
啮齿动物用它们的触须（胡须）来感知和导航环境。这种感觉信息的主要目标是中脑的上级丘，大鼠可以利用它来检测行为环境中有意义的胡须刺激。在这里，我们使用的场电位，单单位和细胞内的记录表明，虽然在上级丘的中间层的细胞反应相对有效地单晶须，细胞反应更强劲，同时，或几乎同时，宽场（多晶须）的刺激。增强的多须反应在时间上是刻板的，由两个短的潜伏期峰值引起的会聚三叉神经突触输入和皮层反馈，分别。这些细胞对多须刺激的时间分散程度和接触顺序高度敏感，这使得它们成为初始多须接触的优秀检测器。此外，由于皮质反馈依赖于前脑激活，它们的输出在静止状态下是最稳健的，这可以作为驱动定向反应的警报信号。
Rodents use their vibrissae (whiskers) to sense and navigate the environment. A main target of this sensory information is the superior colliculus in the midbrain, which rats can use to detect meaningful whisker stimuli in behavioral contexts. Here we used field potential, single-unit and intracellular recordings to show that although cells in the intermediate layers of the superior colliculus respond relatively effectively to single whiskers, the cells respond much more robustly to simultaneous, or nearly simultaneous, wide-field (multiwhisker) stimuli. The enhanced multiwhisker response is temporally stereotyped, consisting of two short latency peaks caused by convergent trigeminal synaptic inputs and cortical feedback, respectively. The cells are highly sensitive to the degree of temporal dispersion and contact order of multiwhisker stimuli, which makes them excellent detectors of initial multiwhisker contact. In addition, their output is most robust during quiescent states, due to the dependence of cortical feedback on forebrain activation, and this may serve as an alerting signal to drive orienting responses.