INTRAGASTRIC CAPSAICIN PROTECTS AGAINST ASPIRIN-INDUCED LESION FORMATION AND BLEEDING IN THE RAT GASTRIC-MUCOSA
INTRAGASTRIC CAPSAICIN PROTECTS AGAINST ASPIRIN-INDUCED LESION FORMATION AND BLEEDING IN THE RAT GASTRIC-MUCOSA
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DOI：
10.1016/0016-5085(89)90508-8
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发表时间：
1989-06-01
期刊：
影响因子：
29.4
通讯作者：
LIPPE, IT
中科院分区：
文献类型：
--
作者：
HOLZER, P;PABST, MA;LIPPE, IT
以往的工作表明，辣椒素敏感的传入神经元参与了胃粘膜防御机制。本研究调查了胃内注射辣椒素对这些神经元的刺激是否对阿司匹林引起的大鼠胃粘膜损伤有保护作用。辣椒素(25-640微米)与酸化(pH 1.5)阿司匹林(25 MM)一起使用，以浓度依赖的方式抑制肉眼可见的病变形成和胃出血。辣椒素(160微米)也能减轻阿司匹林引起的胃电势差的下降。在光镜和扫描电子显微镜下，辣椒素(160微米)对阿司匹林引起的胃损伤也有抑制作用。单用阿司匹林就会导致胃表面上皮大量消融，导致固有层暴露。在辣椒素的存在下，粘膜损伤的深度、完全去除表面上皮细胞的面积和表面脱屑的严重程度都有所减轻。由于辣椒素是薄传入神经元的选择性刺激剂，这些神经元似乎参与了胃防御机制，以对抗阿司匹林的损伤。尽管对表面上皮细胞的损伤也有一定程度的减轻，但传入神经介导的胃保护似乎是防止出血损伤的主要作用。
Previous work has indicated that capsaicin-sensitive afferent neurons are involved in gastric mucosal defense mechanisms. The present study investigated whether stimulation of these neurons by intragastric administration of capsaicin would protect against aspirin-induced mucosal damage in the luminally perfused rat stomach. Capsaicin (25-640 .mu.M), administered together with acidified (pH 1.5) aspirin (25 mM), inhibited macroscopically visible lesion formation and gastric bleeding in a concentration-dependent fashion. Capsaicin (160 .mu.M) also attenuated the aspirin-induced fall in the gastric potential difference. An inhibitory effect of capsaicin (160 .mu.M) on aspirin-induced gastric injury was also seen by light and scanning electron microscopy. Aspirin alone caused a vast ablation of the gastric surface epithelium, resulting in exposure of the lamina propria. In the presence of capsaicin, the depth of mucosal injury, the area totally deprived of surface epithelial cells, and the severity of surface desquamation were diminished. As capsaicin is a selective stimulant of thin afferent neurons, it would appear that these neurons participate in mechanisms of gastric defense against aspirin injury. Prevention of hemorrhagic damage seems to be the primary effect of afferent nerve-mediated gastroprotection, although injury to the surface epithelium is also reduced to some degree.