Serum insulin-like growth factor-1 (IGF-1) during CF pulmonary exacerbation: trends and biomarker correlations.
Serum insulin-like growth factor-1 (IGF-1) during CF pulmonary exacerbation: trends and biomarker correlations.
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DOI：
10.1002/ppul.22822
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发表时间：
2014-04
影响因子：
3.1
通讯作者：
Ashare A
中科院分区：
文献类型：
--
作者：
Gifford AH;Nymon AB;Ashare A
囊性纤维化 (CF) 的特点是循环中胰岛素样生长因子-1 (IGF-1) 水平较低，IGF-1 是一种由肝脏产生的激素，负责控制合成代谢并影响免疫细胞功能。由于 CF 肺部病情加重 (CFPE) 的治疗通常会改善体重和肺功能，因此我们质疑血清 IGF-1 趋势是否是这些反应的象征。最初，我们比较了患有 CF 的健康成人和年龄相近的对照者之间的血清水平。然后我们在整个 CFPE 周期中测量血清 IGF-1。我们还研究了 CFPE 期间 IGF-1 和其他血清生物标志物之间的相关性。收集了人体测量、肺活量测量和人口统计数据。通过ELISA测量血清IGF-1浓度。正常健康状态下的 CF 受试者的血清 IGF-1 水平低于对照组。 CFPE 开始时血清 IGF-1 浓度较基线显着下降。静脉注射抗生素治疗与血清 IGF-1 水平、体重指数 (BMI) 和 1 秒预测用力呼气量百分比 (FEV1%) 的显着改善相关。在CFPE早期和晚期，血清IGF-1与FEV1%、血清铁、血红蛋白浓度和转铁蛋白饱和度（TSAT）直接相关，与α-1-抗胰蛋白酶间接相关。这项研究不仅支持 CF 以 IGF-1 缺乏为特征的范式，而且还支持肺功能、营养状况和血清 IGF-1 的趋势相关。 CFPE 抗生素治疗后所有三个参数的改善可能凸显了 CF 患者肺功能和营养状况之间的联系。IGF-1 和铁相关血液学参数之间的密切相关性表明 IGF-1 可能参与 CF 铁稳态，这是已知受 CFPE 影响的另一个过程。
Cystic fibrosis (CF) is characterized by low circulating levels of insulin-like growth factor-1 (IGF-1), a hormone produced by the liver that governs anabolism and influences immune cell function. Because treatment of CF pulmonary exacerbation (CFPE) often improves body weight and lung function, we questioned whether serum IGF-1 trends were emblematic of these responses. Initially, we compared serum levels between healthy adults with CF and controls of similar age. We then measured serum IGF-1 throughout the CFPE cycle. We also investigated correlations among IGF-1 and other serum biomarkers during CFPE. Anthopometric, spirometric, and demographic data were collected. Serum IGF-1 concentrations were measured by ELISA. CF subjects in their usual state of health had lower serum IGF-1 levels than controls. Serum IGF-1 concentrations fell significantly from baseline at the beginning of CFPE. Treatment with intravenous antibiotics was associated with significant improvement in serum IGF-1 levels, body mass index (BMI), and percent-predicted forced expiratory volume in 1 sec (FEV1%). At early and late CFPE, serum IGF-1 was directly correlated with FEV1%, serum iron, hemoglobin concentration, and transferrin saturation (TSAT) and indirectly correlated with alpha-1-antitrypsin. This study not only supports the paradigm that CF is characterized by IGF-1 deficiency but also that trends in lung function, nutritional status, and serum IGF-1 are related. Improvements in all three parameters after antibiotics for CFPE likely highlight the connection between lung function and nutritional status in CF Close correlations among IGF-1 and iron-related hematologic parameters suggest that IGF-1 may participate in CF iron homeostasis, another process that is known to be influenced by CFPE.